Effect of Bilberry (European Blueberries) and Grape Polyphenols on Cognition and Blood Parameters in Normal, Aged Men With Subjective Memory Decline
| Registry | NCT00972972, acronym BLUEBERRY |
|---|---|
| Status | Unknown |
| Phase | Early Phase 1 |
| Study type | Interventional; randomized, parallel, masking: triple, basic science |
| Enrollment | 61 (Actual) |
| Sponsor | Ullevaal University Hospital (Other); collaborators: University of Oslo |
| Conditions | Memory, Gene Expression |
| Interventions | bilberry (European blueberries) and red grape juice, placebo juice (Dietary supplement) |
| Dates | start 2006-12-01, primary completion 2007-07-01 (estimated), completion 2009-12-01 (estimated), first posted 2009-09-09, last updated 2009-09-15 |
| Locations | 1 site in Norway |
Related Papers Related Patents Related Grants Related Experts
All trials for Memory All trials for Gene Expression All trials of bilberry (European blueberries) and red grape juice All trials of placebo juice
The purpose of this study is to determine whether dietary intervention with blueberry and grape juice extracts in elderly men with subjective memory problems would raise performance on neuropsychological memory tests and change biomarker of muscle damage and whole blood gene expression profiles.
A number of studies have shown that increased dietary intake of fruits and vegetable extracts high in antioxidants (e.g., blueberries, strawberries and spinach) can retard and even reverse age-related decline in brain function and in cognitive and motor performance in rats. This is the first placebo-controlled human study to evaluate the effect of dietary intake of fruit polyphenols on neuropsychological test scores and whole blood gene regulation
Sixty-two non-demented, non-depressed men (age 67-77 years) with subjective memory decline, were randomly assigned to a blueberry/grape juice- and placebo-group in a 9 week double blind intervention study. Pre- and post treatment assessment were measured with a computerised neuropsychological test battery (CANTAB), including tests for motor speed, visual reaction time, and spatial memory. Dietary habits were registered before intervention and several clinical biomarkers were measured in plasma/serum before and after the intervention. Pre- and post intervention-samples for measurement of gene regulation were also collected
| Arm | Type | Interventions | Description |
|---|---|---|---|
| dietary supplement | Active comparator | Dietary Supplement: bilberry (European blueberries) and red grape juice | Extracts of bilberry (European blueberries) and red grape juice (Merlot grapes; Vitis Vinifera L.) |
| placebo dietary supplement | Placebo comparator | Dietary Supplement: placebo juice | Placebo juice extracts |
Sex: Male, ages: 67 Years to 77 Years, accepts healthy volunteers
Inclusion Criteria: * men * age 67-77 years * gradual subjective memory decline * response to advertisement Exclusion Criteria: * head trauma with loss of consciousness and lasting symptoms * brain stroke within last 3 years * dementia, clinically diagnosed * signs of brain-degenerative disease * Mini Mental Status Examination score less than 26 * depression (MADRS; Montgomery Asberg Depression Rating Scale score above 20) * ongoing treatment for cancer (cytostatica)/diabetes * reported or observed serious mental illness * reported or observed use of narcotics (any, present or past) * reported or observed abuse of alcohol * visual, auditory, or motor handicaps of relevance for performance
| Facility | City | Country | Status |
|---|---|---|---|
| Ulleval University Hospital HF | Oslo | Norway |