Trial Using Impella LP 2.5 System in Patients With Acute Myocardial Infarction Induced Hemodynamic Instability

• Impella LP 2.5 (Device): Insertion of the LP 2.5 IMPELLA circulatory support system that can be placed across the aortic valve using a single femoral site. The device pumps blood from the left ventricle into the ascending aorta at 2.5L/min.
• Intra-Aortic Balloon Pump (Device): The Intra-Aortic Balloon Pump consists of a cylindrical balloon that sits in the aorta and counterpulsates.

Primary outcomes

• Composite rate of major adverse events within 30 days or hospital discharge. [30 days or discharge]: Composite rate of major adverse events within 30 days or hospital discharge.

Secondary outcomes

• Maximum CPO increase from baseline. [Treatment]: Maximum CPO increase from baseline.

Sex: All, ages: 18 Years to 90 Years

Inclusion Criteria:

* Informed Consent
* Subject presenting with STEMI undergoing primary PCI
* Patient presents with at least 1 of the following:
* Unstable blood pressure
* Tachycardia and tissue hypoperfusion
* The need for intravenous pressor or inotropic support
* Patient presents with STEMI:
* CK-MB>2x normal

Exclusion Criteria:

* Unwitnessed cardiac arrest
* Abnormalities of the aorta
* Recent stroke or TIA
* Mural thrombus in the left ventricle

• William O'Neill, M.D., Principal investigator, Not affiliated with Abiomed