Aortic Dimensions in Turner Syndrome

NCT00624949 — Unknown, 102 participants, University of Aarhus

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Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.

RegistryNCT00624949
StatusUnknown
Study typeObservational
Enrollment102 (Actual)
SponsorUniversity of Aarhus (Other)
ConditionsTurner Syndrome
Datesstart 2003-08-01, primary completion 2012-06-01 (estimated), completion 2012-06-01 (estimated), first posted 2008-02-28, last updated 2008-02-28

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-Summary

An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

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+Arms and interventions

ArmTypeInterventionsDescription
1women with Turner syndrome
2.Control women

+Outcome measures

Primary outcomes

  • Aortic diameter at 3 well-defined levels measured by MRI and ECHO [2-yearly for 6 years]

Secondary outcomes

  • 24hour ambulatory blood pressure [24h 2-yearly for 6 years]

+Eligibility

Sex: Female, ages: 18 Years to 70 Years, accepts healthy volunteers

Inclusion Criteria:

* Turner syndrome
* Age 18-70 years

Exclusion Criteria:

* Extreme adipositas
* Contraindications to a MRI scan
* Malignant disease

+Publications

  • Results publication: Viuff M, Skakkebaek A, Johannsen EB, Chang S, Pedersen SB, Lauritsen KM, Pedersen MGB, Trolle C, Just J, Gravholt CH. X chromosome dosage and the genetic impact across human tissues. Genome Med. 2023 Mar 28;15(1):21. doi: 10.1186/s13073-023-01169-4. PMID 36978128
  • Results publication: Trolle C, Mortensen KH, Bjerre M, Hougaard DM, Cohen A, Andersen NH, Gravholt CH. Osteoprotegerin in Turner syndrome - relationship to aortic diameter. Clin Endocrinol (Oxf). 2015 Mar;82(3):397-403. doi: 10.1111/cen.12522. Epub 2014 Jul 2. PMID 24923356
  • Results publication: Trolle C, Mortensen KH, Pedersen LN, Berglund A, Jensen HK, Andersen NH, Gravholt CH. Long QT interval in Turner syndrome--a high prevalence of LQTS gene mutations. PLoS One. 2013 Jul 25;8(7):e69614. doi: 10.1371/journal.pone.0069614. Print 2013. PMID 23936059