10 completed, 3 unknown, 2 not yet recruiting, 2 terminated. 13 Not applicable, 4 Phase 2, 2 Early Phase 1, 2 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of L-Tyrosine and Caffeine on Performance in Elite Boxers Placebo, L-Tyrosine, Caffeine - Sports Performance | Not applicable | Not yet recruiting | Inonu University | 18 | 2026-09-01 | 2026-07-08 |
| Efficacy of Topical Tyrosine Versus Topical 5-Fluorouracil With Fractional Erbium YAG Laser Tyrosine - Focal Vitiligo | Early Phase 1 | Recruiting | Aswan University | 40 | 2026-06-01 | 2026-08-11 |
| Tyrosine Vs Tacrolimus With NB-UVB in Vitiligo Narrowband UVB Phototherapy, Topical Tacrolimus 0.1% ointment, Topical Tyrosine 2% cream - Vitiligo | Not applicable | Completed | Minia University | 67 | 2025-08-01 | 2026-10-08 |
| Trial to Evaluate the Efficacy of a Zinc, Selenium, and L-Tyrosine Supplement in the Prevention of Thyrotoxicosis in Subjects With r25191G/A SEPP1 Polymorphism zinc, selenium, and L-tyrosine in SEPP1, Placebo - Thyrotoxicosis | Not applicable | Not yet recruiting | S.LAB (SOLOWAYS) | 150 | 2025-07-30 | 2025-06-08 |
| Contribution of L-Tyrosine to Human Decision Making in Stressful Situations Blood collection, L-Tyrosine 500 Mg, Placebo - Stress, Psychological | Not applicable | Completed | Direction Centrale du Service de Santé des Armées | 17 | 2021-11-18 | 2022-11-25 |
| Contribution of L-Tyrosine to Recovery From Operational Strain on Return From External Operation Blood collection, L-Tyrosine 500 Mg, Psychological questionnaires - Stress, Psychological | Not applicable | Completed | Direction Centrale du Service de Santé des Armées | 116 | 2020-09-09 | 2022-11-25 |
| Identification of P-cresyl Sulfate Producer Phenotype by Oral Tyrosine Challenge Test: Interactions Among Diet, Gut Microbiota, and Host Genome Tyrosine, brand name: myprotein - Chronic Kidney Diseases, Healthy | Not applicable | Unknown | Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation | 80 | 2019-12-16 | 2020-01-18 |
| Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer Linaclotide, Placebo - Colorectal Adenoma, Stage 0 Colorectal Cancer AJCC v8 | Phase 2 | Active not recruiting | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 150 | 2019-10-30 | 2026-10-08 |
| Modulating Glucose Tolerance With Dietary Tyrosine Tyrosine (TYR) Supplementation - Glucose Tolerance | Not applicable | Completed | Columbia University | 10 | 2019-08-07 | 2021-05-05 |
| Mod of Cognitive Flexibility by tDCS, Tyrosine Polymorphisms in the COMT Gene tdcs (sham/anodal) + drug (placebo/tyrosine) - Modulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT Gene | Not applicable | Unknown | Sheffield Hallam University | 32 | 2019-02-18 | 2019-04-04 |
| Dopamine Dorsolateral Prefrontal Cortex Behavioural Flexibility Cathodal Transcranial direct current stimulation, L-Tyrosine, Transcranial direct current stimulation (sham) - Cognitive Change | Not applicable | Completed | Sheffield Hallam University | 24 | 2017-03-01 | 2018-02-22 |
| Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression. L-tyrosine, L-Tryptophan, deplin - Depression | Not applicable | Withdrawn | John D. Dingell VA Medical Center | 2015-11-01 | 2020-02-21 | |
| The Effects of L-Tyrosine on 24 Hour Blood Pressure and Heart Rate in Parkinson's Disease L-tyrosine, Sugar Pill - Blood Pressure | Early Phase 1 | Completed | New York Institute of Technology | 6 | 2014-10-01 | 2016-01-20 |
| Treatment of TNNT1-Myopathy With L-Tyrosine. L-Tyrosine, Placebo - Nemaline Myopathy | Phase 2 | Unknown | Hadassah Medical Organization | 10 | 2014-01-01 | 2014-01-14 |
| The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease Tyrosine, Placebo Comparator:Sugar Pill - Parkinson's Disease | Phase 1 / Phase 2 | Completed | New York Institute of Technology | 40 | 2012-09-01 | 2014-04-16 |
| Efficacy of Tyrosine in Restless Legs Syndrome L-Tyrosine - Restless Legs Syndrome (RLS) | Not applicable | Completed | Seton Healthcare Family | 5 | 2012-01-01 | 2017-04-27 |
| Pharmacotoxicology of Trichloroethylene Metabolites Dichloroacetate, Genotyping, Leucine - Healthy | Not applicable | Terminated | University of Florida | 2 | 2011-08-01 | 2015-06-03 |
| L-Tyrosine Supplementation in Patients With Fibromyalgia Tyrosine, Placebo - Fibromyalgia | Not applicable | Terminated | Icahn School of Medicine at Mount Sinai | 15 | 2010-01-01 | 2017-04-11 |
| B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients tyrosine, green tea, caffeine - Obesity | Phase 1 | Completed | University of Copenhagen | 12 | 2000-01-01 | 2006-03-14 |
| Tyrosine for Methamphetamine Dependence - 1 Tyrosine - Amphetamine-Related Disorders | Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 89 | 1997-04-01 | 2017-01-12 |
Stress, Psychological (2) · Amphetamine-Related Disorders (1) · Colorectal Neoplasms (1) · Depression (1) · Fatigue (1) · Fibromyalgia (1) · Hypotension, Orthostatic (1) · Myopathies, Nemaline (1) · Obesity (1) · Pain (1) · Parkinson Disease (1) · Renal Insufficiency, Chronic (1) · Restless Legs Syndrome (1) · Thyrotoxicosis (1) · Vitiligo (1)
Direction Centrale du Service de Santé des Armées (2) · New York Institute of Technology (2) · Sheffield Hallam University (2) · Aswan University (1) · Columbia University (1) · Hadassah Medical Organization (1) · Icahn School of Medicine at Mount Sinai (1) · Inonu University (1) · John D. Dingell VA Medical Center (1) · Minia University (1) · National Institute on Drug Abuse (NIDA) (1) · S.LAB (SOLOWAYS) (1) · Seton Healthcare Family (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (1)
United States (9) · Egypt (2) · France (2) · United Kingdom (2) · Denmark (1) · Israel (1) · Russia (1) · Taiwan (1) · Turkey (Türkiye) (1)
Luca Aquili, Ph.D. (2) · Almostafa M Ahmed (1) · Astrup Arne, Prof (1) · Gantt Galloway, Pharm.D. (1) · Joanne DiFrancisco-Donoghue, PhD (1) · Joanne Donoghue, PhD (1) · Judith Korner, MD (1) · Michael A Mazzeffi, MD, MPH (1) · Peter W Stacpoole, PhD, MD (1) · Scott Waldman, MD (1) · Ting-Yun Lin, MD. (1)
R01DK104740 (1), R01ES014617 (1)