11 completed, 3 unknown, 2 active not recruiting, 2 not yet recruiting. 18 Not applicable, 3 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Completed 7, Active not recruiting 2, Not yet recruiting 2, Recruiting 2, Unknown 2, Withdrawn 2, Terminated 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation transcranial direct current stimulation, Sham transcranial direct current stimulation - PARKINSON DISEASE (Disorder) | Not applicable | Recruiting | The University of Texas at Dallas | 20 | 2026-09-15 | 2026-09-16 |
| Closed-loop tES-non-invasive Stimulation Transcranial low intensity focused ultrasound (FUS), transcranial electrical stimulation, Magnetic Resonance Imaging - Closed-loop Brain Stimulation | Not applicable | Not yet recruiting | University of Nottingham | 30 | 2026-09-01 | 2026-08-19 |
| Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation - Anxiety, PTSD | Not applicable | Active not recruiting | Tactical Mind Research Coalition, Inc. | 240 | 2026-08-01 | 2026-09-16 |
| Evaluation of an Electric Stimulator for Medical Use by Personal (LRTPM1) for Visual Function in Early to Intermediate Dry Age-Related Macular Degeneration Transcutaneous Electrical Stimulation, Sham Transcutaneous Electrical Stimulation - Dry Age-Related Macular Degeneration, AMD | Not applicable | Not yet recruiting | Nu Eyne Co., Ltd. | 40 | 2026-07-09 | 2026-07-13 |
| Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating Diseases tES - Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 40 | 2024-12-15 | 2026-08-19 |
| Transcranial Electrical Stimulation in Subacromial Pain Syndrome Strenghtening + TES - Subacromial Pain Syndrome | Not applicable | Withdrawn | University of Valencia | 2023-01-23 | 2026-06-11 | |
| Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment NITESGON, Lidocaine / Prilocaine Topical Cream, C5/C6 stimulation - Mild Cognitive Impairment, Memory Impairment | Phase 1 / Phase 2 | Completed | University of Dublin, Trinity College | 80 | 2022-09-01 | 2026-01-26 |
| Electrical Brain Stimulation for Cognitive Impairment in Schizophrenia: a tDCS-fMRI Study transcranial direct current stimulation - Schizophrenia, Cognitive Impairment | Phase 1 | Unknown | The National Brain Mapping Laboratory (NBML) | 30 | 2022-02-01 | 2023-11-13 |
| Retrospective NIS to Evaluate the Patient Benefit of TES Transcorneal Electrostimulation via OkuStim System - Retinitis Pigmentosa | Completed | Okuvision GmbH | 49 | 2021-09-06 | 2022-08-22 | |
| Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI TMS or tES, sham TMS or tES - Behavior and Behavior Mechanisms | Not applicable | Unknown | Christian Ruff | 1800 | 2021-09-01 | 2021-08-30 |
| Feasibility of Home-based tES for Older Adults at Risk of Falling tES (transcranial electrical stimulation) - Aging, Accidental Falls | Not applicable | Active not recruiting | Hebrew SeniorLife | 72 | 2021-01-25 | 2026-04-23 |
| The Assessment of Fatigue and Quality of Life in Patients With Bone Tumor, assessment scales (BFI, QLQ, TESS) - Fatigue Syndrome, Chronic, Bone Tumor | Completed | Istituto Ortopedico Rizzoli | 155 | 2019-07-26 | 2024-07-18 | |
| Neurophysiologic Signatures of Trigeminal Neuralgia Pain transcranial electrical brain stimulation - Trigeminal Neuralgia (TN) | Not applicable | Completed | University of Florida | 61 | 2019-02-01 | 2022-10-06 |
| The Safety and Efficacy of Nexalin Trans-cranial Electrical Stimulation Stimulation for the Treatment of Depression Nexalin Based Trans-Cranial Electrical Stimulation - Depression | Not applicable | Completed | University of Pennsylvania | 101 | 2017-09-01 | 2019-10-28 |
| Transcranial Electrical Stimulation for mTBI TES - Mild Traumatic Brain Injury (mTBI), Post-traumatic Stress Disorder | Not applicable | Completed | VA Office of Research and Development | 66 | 2017-02-01 | 2024-01-18 |
| Transcorneal Electrical Stimulation (TES) for the Treatment of Amblyopia OkuStim®, Sham-OkuStim® - Amblyopia | Not applicable | Unknown | Wills Eye | 40 | 2015-07-01 | 2020-03-05 |
| A Sequenced Behavioral and Medication Intervention for Cocaine Dependence Computer-assisted behavior therapy, Mixed-Amphetamine Salts- Extended Release (MAS-ER), Placebo - Cocaine Dependence | Phase 1 / Phase 2 | Completed | New York State Psychiatric Institute | 145 | 2014-01-01 | 2022-01-25 |
| Trial to Show Non-inferiority / Superiority of an Endoscopic Transforaminal Discectomy to Standard Microdiscectomy joimax TESSYS, Microdiscectomy - Lumbar Disc Herniation | Not applicable | Withdrawn | Joimax GmbH | 2013-09-01 | 2017-09-25 | |
| Electric Stimulation of the Eye to Improve Vision After Trauma Transcorneal Electrical Stimulation, Sham - Non-arteritic Anterior Ischemic Optic Neuropathy (NAION), Trauma | Not applicable | Completed | Wills Eye | 97 | 2013-07-01 | 2020-01-18 |
| Transcorneal Electrical Stimulation - Multicenter Safety Study Transcorneal electrostimulation - Retinitis Pigmentosa | Not applicable | Completed | Okuvision GmbH | 105 | 2012-09-01 | 2021-03-04 |
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Retinitis Pigmentosa (3) · Cognitive Dysfunction (2) · Stress Disorders, Post-Traumatic (2) · Substance-Related Disorders (2) · Amblyopia (1) · Anxiety Disorders (1) · Attention Deficit Disorder with Hyperactivity (1) · Behavior (1) · Behavior, Addictive (1) · Bone Neoplasms (1) · Brain Concussion (1) · Cocaine-Related Disorders (1) · Depression (1) · Eye Injuries (1) · Fatigue Syndrome, Chronic (1)
Okuvision GmbH (3) · New York State Psychiatric Institute (2) · Wills Eye (2) · Asociación para Evitar la Ceguera en México (1) · Christian Ruff (1) · Hebrew SeniorLife (1) · Istituto Ortopedico Rizzoli (1) · Joimax GmbH (1) · Nu Eyne Co., Ltd. (1) · Tactical Mind Research Coalition, Inc. (1) · The National Brain Mapping Laboratory (NBML) (1) · The University of Texas at Dallas (1) · University of Dublin, Trinity College (1) · University of Florida (1) · University of Nottingham (1)
United States (10) · Germany (4) · Austria (1) · China (1) · Denmark (1) · Iran (1) · Ireland (1) · Italy (1) · Mexico (1) · Norway (1) · South Korea (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Brad Manor, PhD (1) · Brian Pinkston, MD, MPH (1) · Cheryl Lowry, MD, MPH (1) · Christian Ruff, PhD (1) · Dohyoung Kim (1) · Edward V Nunes, MD (1) · Florian Gekeler, Prof Dr med (1) · Florian Gekeler, Prof. Dr. (1) · Frances R Levin, M.D. (1) · Hendrik Scholl, Prof. Dr. (1) · John Hart, MD (1) · John K Neubert, DDS, MS (1) · Julia Haller, MD (1) · Katarina Stingl, Prof. Dr. (1)
PMID 22790224, PMID 24708748, PMID 25671593, PMID 25697725, PMID 26880594, PMID 28114587, PMID 31775146, PMID 33086160, PMID 34366201, PMID 36117569, PMID 37732961, PMID 39577033, PMID 8433390
R01DA034087 (1), U10DA013035 (1)