12 completed, 2 unknown, 2 withdrawn, 1 not yet recruiting. 7 Phase 3, 4 Not applicable, 3 Phase 4, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 7 | Completed 7 |
| Not applicable | 4 | Completed 3, Unknown 1 |
| Phase 4 | 3 | Completed 2, Unknown 1 |
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
Follow Streptokinase: new trials by email Literature Review of Streptokinase trials Research Report on Streptokinase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| To Compare the Efficacy & Safety of Ultra-Slow (24 hr) Low Dose (25 mg) Infusion of Alteplase Over Slow (24hr) Infusion of Streptokinase in Mechanical Prosthetic Valve Thrombosis Alteplase, streptokinase - Thrombolysed | Not applicable | Completed | U. N. Mehta Institute of Cardiology and Research Center | 100 | 2024-11-01 | 2026-01-26 |
| Systemic Thrombolysis Versus Catheter Directed Management for Acute Intermediate-high Pulmonary Embolism Streptokinase Injection, Penumbra System - Acute Pulmonary Embolism | Not yet recruiting | Assiut University | 50 | 2024-10-01 | 2024-08-09 | |
| Catheter Directed Interventions in Pulmonary Embolism catheter directed fragmentation and thrombolysis, Streptokinase - Pulmonary Embolism | Not applicable | Unknown | Assiut University | 60 | 2018-09-01 | 2018-07-24 |
| Intramyocardial Haemorrhage in Patients With Primary STEMI Pharmaco-invasive strategy, Primary PCI - Myocardial Infarction, STEMI | Not applicable | Completed | Tomsk National Research Medical Center of the Russian Academy of Sciences | 60 | 2018-01-25 | 2026-06-26 |
| Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital streptokinase, MESNA (2-mercaptoethane sulfonate Na), Medical thoracoscopy - Pleural Effusion | Phase 4 | Unknown | Assiut University | 100 | 2017-08-01 | 2017-06-06 |
| Streptokinase Versus Unfractionated Heparin Nebulization in Severe ARDS Unfractionated heparin, Streptokinase - Acute Respiratory Distress Syndrome, Severe Acute Respiratory Syndrome | Phase 3 | Completed | Beni-Suef University | 60 | 2016-02-18 | 2018-03-14 |
| Acute Coronary Syndrome Sri Lanka Audit Project aspirin, clopidogrel, statin, enoxaparin, streptokinase - Acute Coronary Syndrome, Unstable Angina | Withdrawn | University of Colombo | 2015-04-01 | 2016-09-16 | ||
| Asia Africa Streptokinase Trial Streptokinase - Ischemic Stroke | Phase 2 | Withdrawn | University of Alberta | 2014-06-01 | 2022-05-27 | |
| Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis streptokinase, Saline irrigation - Acute Pancreatitis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 28 | 2013-05-01 | 2016-07-07 |
| A Trial Using Double-Bolus THR-100 Versus Streptokinase THR-100, Streptokinase - Acute Myocardial Infarction | Phase 3 | Completed | Bharat Biotech International Limited | 120 | 2010-10-01 | 2021-02-23 |
| Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction Streptokinase, primary percutaneous coronary intervention - Acute Coronary Syndromes, Acute Myocardial Infarction | Phase 4 | Completed | Istanbul University | 53 | 2007-01-01 | 2009-06-23 |
| A Study Comparing a New Dosing Regimen of Clot-dissolving Drug for Mechanical Heart Valves Which Show Clots Streptokinase - Prosthetic Valve Thrombosis | Phase 3 | Completed | All India Institute of Medical Sciences | 120 | 2004-11-01 | 2013-10-24 |
| Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction intracoronary infusion,, primary percutaneous coronary angioplasty - Acute Myocardial Infarction | Phase 4 | Completed | Istanbul University | 95 | 2004-10-01 | 2008-08-01 |
| A Study to Investigate the Procoagulant Effect of Tenecteplase (TNK-tPA), Alteplase (Rt-PA) and Streptokinase (SK) Administered to Patients With Acute Myocardial Infarction (AMI) Tenecteplase, Alteplase, Streptokinase - Myocardial Infarction | Phase 3 | Completed | Boehringer Ingelheim | 49 | 2000-05-01 | 2014-07-14 |
| Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve Thrombosis Streptokinase, Tissue plasminogen activator, Tissue Plasminogen Activator - Prosthetic Valve Thrombosis | Not applicable | Completed | Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital | 182 | 1993-01-01 | 2011-10-13 |
| Intravenous Streptokinase in Acute Myocardial Infarction streptokinase - Cardiovascular Diseases, Coronary Disease | Phase 3 | Completed | University of Washington | 1983-08-01 | 2016-02-10 | |
| Randomized Clinical Trial of Non-Surgical Reperfusion of the Coronary Arteries nitroglycerin, streptokinase, heart catheterization - Cardiovascular Diseases, Coronary Disease | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1982-08-01 | 2013-11-26 |
Myocardial Infarction (4) · Acute Coronary Syndrome (2) · Cardiovascular Diseases (2) · Coronary Disease (2) · Heart Diseases (2) · Myocardial Ischemia (2) · ST Elevation Myocardial Infarction (2) · Angina, Unstable (1) · Coronary Artery Disease (1) · Ischemic Stroke (1) · Non-ST Elevated Myocardial Infarction (1) · Pancreatitis (1) · Pancreatitis, Acute Necrotizing (1) · Pleural Effusion (1) · Pulmonary Embolism (1)
Assiut University (3) · Istanbul University (2) · All India Institute of Medical Sciences (1) · Beni-Suef University (1) · Bharat Biotech International Limited (1) · Boehringer Ingelheim (1) · Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Tomsk National Research Medical Center of the Russian Academy of Sciences (1) · U. N. Mehta Institute of Cardiology and Research Center (1) · University of Alberta (1) · University of Colombo (1) · University of Washington (1)
India (3) · Turkey (Türkiye) (3) · Egypt (1) · Russia (1) · Sri Lanka (1)
Berrin Umman, Prof. (2) · Sabahattin Umman, Prof. (2) · Ahmet K Bilge, M.D. (1) · Arif O Cimen, M.D. (1) · Ashfaq Shuaib, MD, FRCPC (1) · Ayman K Mohamed, PHD (1) · Cuneyt Turkmen, Assoc. Prof. (1) · Dr.A Singh, MBBS, MD (1) · Emre K Aslanger, M.D. (1) · Evgeny V. Vyshlov (1) · Ganesan Karthikeyan, MD, DM (1) · Hatem Hatem Elmoutaz Mahmoud, MD (1) · Huseyin Oflaz, Assoc.Prof. (1) · Irem Okcular, M.D. (1) · Isik Adalet, Prof. (1)
PMID 17476008, PMID 19738134, PMID 19744615, PMID 21416132, PMID 22779430, PMID 23489534, PMID 25212800, PMID 26763281, PMID 39861441
R01HL028843 (1), R01HL030300 (1)