9 recruiting, 4 active not recruiting, 4 unknown, 1 completed. 15 Phase 2, 4 Phase 1, 3 Not applicable, 1 Phase 3.
Follow Low-dose radiotherapy: new trials by email Literature Review of Low-dose radiotherapy trials Research Report on Low-dose radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer Low-dose radiotherapy, Pucotenlimab, CAPEOX/XELOX - Colorectal Cancer (CRC) | Phase 2 | Recruiting | Sun Yat-sen University | 50 | 2026-03-15 | 2026-10-15 |
| Perioperative Chemotherapy With Low-Dose Radiotherapy and Tislelizumab for Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Low Dose Radiotherapy Combined with Tislelizumab and Chemotherapy, Chemotherapeutic Agent, low-dose radiotherapy - Gastric or Gastroesophageal Junction Adenocarcinoma | Phase 2 | Not yet recruiting | Jiangsu Cancer Institute & Hospital | 114 | 2026-02-26 | 2026-02-13 |
| Low-Dose Radiotherapy and Anti-PD-1 Immunotherapy as Neoadjuvant Treatment for Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma Neoadjuvant and Adjuvant Immunotherapy, Low-dose radiotherapy, Surgery - Locally Advanced Head and Neck Squamous Cell Carcinoma | Phase 2 | Recruiting | Rui You | 22 | 2025-12-15 | 2026-09-01 |
| LDRT Combined With Pucotenlimab and Standard Therapy for Advanced Pancreatic Cancer: A Single-Arm Study Low-dose Radiotherapy, Pucotenlimab, AG regimen - Pancreatic Cancer, PD-L1 | Phase 1 / Phase 2 | Recruiting | Zhejiang Provincial People's Hospital | 10 | 2025-09-30 | 2026-01-26 |
| Low-dose Radiotherapy Combined With Concurrent Chemotherapy, Toripalimab and Tifcemalimab in the Treatment of ES-SCLC Low-dose radiotherapy, Tifcemalimab injection, Toripalimab - Extensive-stage Small-cell Lung Cancer | Phase 1 | Withdrawn | Sichuan University | 2025-01-10 | 2026-04-29 | |
| Low-dose Radiotherapy Combined With Chemotherapy and AK112 as Second-line Treatment in Patients With Advanced G/GEJ Cancer Low-dose radiotherapy, albumin-bound paclitaxel, AK112 - Gastric Cancer | Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 45 | 2024-07-10 | 2025-01-24 |
| AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy Cadonilimab, Low-dose radiotherapy, SBRT - Head and Neck Squamous Cell Carcinoma | Phase 2 | Recruiting | Fudan University | 52 | 2024-07-03 | 2025-06-04 |
| Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma Tislelizumab, Low-dose radiotherapy, Nab-paclitaxel - Esophageal Squamous Cell Carcinoma | Phase 2 | Recruiting | Sichuan University | 30 | 2024-06-30 | 2025-06-06 |
| Phase 1b/2 Study of LDRT in Combination With AK104 Plus Chemotherapy as First-line Treatment for ES-SCLC AK104, Etoposide, Carboplatin - SCLC, Extensive Stage | Phase 1 / Phase 2 | Active not recruiting | Sichuan University | 57 | 2024-05-16 | 2026-04-29 |
| Safety and Tolerability of LDRT+Sugemalimab+Chemotherapy+Olaparib for First-Line Treatment of SLFN-11 Positive ES-SCLC Low-dose radiotherapy, Etoposide, Cisplatin - Lung Cancer, Extensive-stage Small-cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Sichuan University | 45 | 2024-04-18 | 2026-05-05 |
| IC Plus Low-dose Radiation Plus Cadonilimab in LANPC Intensity Modulated Radiation Therapy, Chemotherapy, Immune checkpoint inhibitor - Nasopharyngeal Carcinoma, Immune Checkpoint Inhibitor | Phase 3 | Recruiting | Sun Yat-sen University | 380 | 2024-01-10 | 2026-05-11 |
| The Efficacy and Safety of Low-dose Radiotherapy Combined With Sintilimab and Temozolomide in Recurrent Glioblastoma Sintilimab, Low-dose Radiotherapy - Recurrent Glioblastoma | Phase 2 | Recruiting | Fifth Affiliated Hospital, Sun Yat-Sen University | 20 | 2023-12-27 | 2024-01-24 |
| Study of Low-Dose Radiotherapy Concurrent Chemotherapy With Serplulimab for Patients With ES-SCLC serplulimab, Cisplatin, Carboplatin - Extensive-stage Small-cell Lung Cancer | Phase 2 | Active not recruiting | Sichuan University | 61 | 2023-03-07 | 2026-04-29 |
| Low-dose Radiotherapy and Neoadjuvant Chemotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma low-dose radiotherapy - Locally Advanced Nasopharyngeal Carcinoma | Not applicable | Unknown | Sichuan Cancer Hospital and Research Institute | 80 | 2022-08-01 | 2022-08-17 |
| Low-dose Radiotherapy in iNHL Low-dose radiotherapy - Indolent Lymphoma, Low-dose Radiotherapy | Phase 2 | Unknown | Chinese Academy of Medical Sciences | 73 | 2022-05-01 | 2022-09-16 |
| Neoadjuvant Chemotherapy and Low-dose Radiotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma low-dose radiotherapy - Nasopharyngeal Carcinoma | Not applicable | Completed | Sichuan Cancer Hospital and Research Institute | 84 | 2022-03-26 | 2024-12-31 |
| The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC Tislelizumab, Low-dose radiotherapy - Head and Neck Squamous Cell Carcinoma, Neoadjuvant Treatment | Phase 2 | Active not recruiting | Fifth Affiliated Hospital, Sun Yat-Sen University | 25 | 2022-03-09 | 2026-09-09 |
| Low-dose Radiotherapy Combined With Durvalumab, Chemotherapy(EP) in the Treatment of ES-SCLC Low-dose radiotherapy, Durvalumab, Etoposide, and cisplatin/carboplatin - Lung Cancer, Extensive-stage Small-cell Lung Cancer | Phase 2 | Active not recruiting | You Lu | 30 | 2022-03-02 | 2026-05-08 |
| Low Dose Anti-inflammatory Radiotherapy for the Treatment of Pneumonia by COVID-19 Low-dose radiotherapy, Hydroxychloroquine Sulfate, Ritonavir/lopinavir - Pneumonia, Viral | Not applicable | Unknown | Grupo de Investigación Clínica en Oncología Radioterapia | 106 | 2020-06-05 | 2021-07-30 |
| Low-dose Radiotherapy for Diffuse Large B-cell Lymphoma Low-dose radiotherapy - Lymphoma | Phase 2 | Unknown | Centro di Riferimento Oncologico - Aviano | 25 | 2011-07-01 | 2016-06-17 |
Small Cell Lung Carcinoma (4) · Lung Neoplasms (2) · Nasopharyngeal Carcinoma (2) · Squamous Cell Carcinoma of Head and Neck (2) · COVID-19 (1) · Colorectal Neoplasms (1) · Diabetes Mellitus, Insulin-Dependent, 12 (1) · Esophageal Squamous Cell Carcinoma (1) · Glioblastoma (1) · Lymphoma (1) · Pancreatic Neoplasms (1) · Pneumonia, Viral (1) · Stomach Neoplasms (1)
Sichuan University (5) · Fifth Affiliated Hospital, Sun Yat-Sen University (2) · Sichuan Cancer Hospital and Research Institute (2) · Sun Yat-sen University (2) · Centro di Riferimento Oncologico - Aviano (1) · Chinese Academy of Medical Sciences (1) · Fudan University (1) · Grupo de Investigación Clínica en Oncología Radioterapia (1) · Jiangsu Cancer Institute & Hospital (1) · Rui You (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · You Lu (1) · Zhejiang Provincial People's Hospital (1)
China (16) · Italy (1) · Spain (1)
You Lu, MD (3) · Angel Montero, MD, PhD (1) · Carlo Furlan, MD (1) · Chong Zhao, MD, PhD (1) · Jianxin Xue, professor (1) · Lu Lu Su, MD (1) · Manel Algara, MD, PhD (1) · Merirxell Arenas, MD, PhD (1) · Pei-Rong Ding (1) · Rui You (1) · Shu Jie Li, MM (1) · Shun Dong Cang, MD (1) · Yan Zhang, MD (1) · Yu Wang, M.D. (1) · Yue Xie, MM (1)