11 completed, 3 terminated, 2 recruiting, 1 unknown. 6 Not applicable, 5 Phase 3, 3 Phase 2, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 4, Recruiting 2 |
| Phase 3 | 5 | Completed 4, Terminated 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
| Phase 4 | 2 | Terminated 1, Unknown 1 |
Follow Fibrin Glue: new trials by email Literature Review of Fibrin Glue trials Research Report on Fibrin Glue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant - CerebroSpinal Fluid (CSF) Leak | Not applicable | Recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 225 | 2025-08-15 | 2025-10-14 |
| Fibrin Glue Versus Titanium Platelet-rich Fibrin in Lateral Sinus Lifting Fibrin Glue, T-PRF, Negative control - Sinus Floor Augmentation, Graftless Sinus Elevation | Not applicable | Completed | Hams Hamed Abdelrahman | 30 | 2022-02-01 | 2023-04-26 |
| Stromal Vascular Fraction (SVF) Cells for Non-Operative Treatment of Small Rotator Cuff Tears Tisseel Injectable Product, Stromal Vascular Fraction Cells - Rotator Cuff Tears | Phase 2 | Withdrawn | AdventHealth | 2022-01-09 | 2023-02-15 | |
| Efficacy of Buccal Pad of Fat, Advanced Platelet Rich Fibrin, Fibrin Glue and Oxidized Cellulose Plug in Management of Oro-Antral Communication, Comparative Clinical Study Buccal Pad of Fat, A-PRF, fibrin glue - Healthy Volunteers Only | Not applicable | Completed | October 6 University | 24 | 2019-01-01 | 2024-01-24 |
| Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery Cauterization, Fibrin glue - Pterygium of Conjunctiva and Cornea | Not applicable | Recruiting | University of Split, School of Medicine | 164 | 2018-05-08 | 2022-11-02 |
| Treatment of Intractable Common Extensor Tendon Injury Using Mesenchymal Stem Cells (Allo-ASC) High concentration of Allo-ASC, Low concentration of Allo-ASC, Fibrin glue - Lateral Epicondylitis | Phase 2 | Completed | Seoul National University Hospital | 30 | 2018-03-15 | 2025-04-06 |
| Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage Bupivacaine, Fibrin Sealant - Pain, Postoperative, Postoperative Hemorrhage | Phase 2 | Terminated | Indiana University | 18 | 2015-03-01 | 2018-08-10 |
| Postoperative Bleeding Prevention in Massive Bone Tumour Resection Tranexamic Acid, Fibrin glue, Electrocauterization - Blood Loss, Bone Tumour | Phase 3 | Terminated | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 56 | 2013-03-01 | 2016-09-20 |
| Prevention of Postoperative Bleeding in Subcapital Femoral Fractures Tranexamic Acid, Fibrin glue, Electrocauterization - Hip Fracture, Blood Loss | Phase 3 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 161 | 2013-02-01 | 2016-09-20 |
| Clinical Trial to Evaluate the Efficacy and Safety of Stem Cells ◦Drug: ASCs. + fibrin glue, fibrin glue - Anal Fistula | Phase 3 | Completed | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 80 | 2013-02-01 | 2018-04-19 |
| Long-term Follow-up After Laparoscopic Inguinal Hernia Repair Using Tisseel for Mesh Fixation Fibrin Sealant, Tissue-penetrating mesh-fixation - Hernia, Inguinal, Recurrence | Completed | Herlev Hospital | 2340 | 2012-07-01 | 2015-03-18 | |
| Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty Tranexamic Acid, Fibrin glue, Habitual haemostasis - Knee Arthropathy | Phase 3 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 172 | 2010-06-01 | 2013-08-28 |
| Fibrin Based Adhesive for the Prevention of Surgical Complications in the Kidney Transplantation Fibrin Glue - Vascular Postoperative Complications, Urological System Complication of Procedure | Phase 3 | Completed | Alejandro Gonzalez-Ojeda | 152 | 2010-05-01 | 2015-03-24 |
| The Application of Fibrin Glue (Tissucol Duo Quick) in External Eye Surgeries Fibrin Glue assisted external eye surgery, Fibrin glue - Corneal Ulcers, Cataract | Not applicable | Completed | National Taiwan University Hospital | 60 | 2009-12-01 | 2014-05-14 |
| Fibrin Glue Versus Tacked Fixation in Groin Hernia Repair (TAPP) Fibrin glue, Tacks - Inguinal Hernia, Femoral Hernia | Not applicable | Completed | Zealand University Hospital | 112 | 2009-09-01 | 2024-08-26 |
| Use of Fibrin Glue in Vitreoretinalsurgery fibrin glue - Surgery | Phase 4 | Terminated | Asociación para Evitar la Ceguera en México | 50 | 2009-05-01 | 2024-05-30 |
| Long-term Safety and Efficacy of Adipose-derived Stem Cells to Treat Complex Perianal Fistulas in Patients Participating in the FATT-1 Randomized Controlled Trial ASCs, Fibrin glue - Complex Perianal Fistula | Completed | Tigenix S.A.U. | 148 | 2008-09-01 | 2019-04-12 | |
| Prevention of Anastomotic Leak in Gastrointestinal (GI) Anastomosis With the Application of Tisseal in the Anastomotic Line Fibrin glue - Anastomotic Leak | Phase 4 | Unknown | Hospital General Universitario Gregorio Marañon | 200 | 2007-06-01 | 2011-03-02 |
Hemorrhage (3) · Hernia, Inguinal (2) · Pain (2) · Anastomotic Leak (1) · Bone Neoplasms (1) · Cataract (1) · Cerebrospinal Fluid Otorrhea (1) · Chronic Pain (1) · Corneal Ulcer (1) · Hematoma (1) · Hernia, Femoral (1) · Hip Fractures (1) · Lymphocele (1) · Oroantral Fistula (1) · Pain, Postoperative (1)
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (3) · AdventHealth (1) · Alejandro Gonzalez-Ojeda (1) · Asociación para Evitar la Ceguera en México (1) · Hams Hamed Abdelrahman (1) · Herlev Hospital (1) · Hospital General Universitario Gregorio Marañon (1) · Indiana University (1) · Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (1) · Maria Sklodowska-Curie National Research Institute of Oncology (1) · National Taiwan University Hospital (1) · October 6 University (1) · Seoul National University Hospital (1) · Tigenix S.A.U. (1) · University of Split, School of Medicine (1)
Spain (6) · Denmark (2) · Egypt (2) · Mexico (2) · United States (2) · Croatia (1) · Poland (1) · South Korea (1) · Taiwan (1)
Aguilera Roig, Xavier (1) · Alejandro Gonzalez-Ojeda, PhD (1) · Andreas Q Fenger, Researcher (1) · Bruce H Matt, MD,MSc (1) · Jacob Rosenberg, M.D. DMSc (1) · Jacob Rosenberg, professor (1) · Martinez Zapata, Mª José (1) · Mette A Tolver, M.D. (1) · Neel M Helvind, Researcher (1) · Poul Juul, M.D. (1) · Sun Gun Chung, MD, PhD (1)
PMID 15933795, PMID 18694359, PMID 19273960, PMID 20636801, PMID 22065114, PMID 22706128, PMID 22748849, PMID 23053677, PMID 23355162, PMID 29950464, PMID 36045358, PMID 40246197
2009 (1)