24 completed, 10 unknown, 5 terminated, 2 recruiting. 19 Not applicable, 8 Phase 4, 3 Phase 2, 3 Phase 3, 2 Phase 1.
Follow Systolic Heart Failure: new trials by email Literature Review of Systolic Heart Failure trials Research Report on Systolic Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heart Failure and Postoperative Outcome in Surgery - a National Registry Study Heart Failure, Diastolic Heart Failure | Not yet recruiting | Umeå University | 2200000 | 2026-08-01 | 2026-06-09 | |
| A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure Airvo 3 - Systolic Heart Failure, Respiratory Failure | Not applicable | Recruiting | Yale University | 50 | 2025-10-04 | 2026-05-28 |
| Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response Left bundle branch area pacing, Cardiac MRI - Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction | Not applicable | Withdrawn | VA Office of Research and Development | 2023-04-30 | 2025-08-11 | |
| Neuromodulation of Inflammation and Endothelial Function neuromodulation device, SHAM - Systolic Heart Failure | Not applicable | Recruiting | University of Oklahoma | 158 | 2022-09-01 | 2026-08-11 |
| Effects of Postural Balance Exercises in Patients With Heart Failure Core stabilization group(CSG), Wobble board group (WBG) - Heart Failure, Systolic Heart Failure | Not applicable | Completed | Giresun University | 42 | 2021-06-15 | 2023-01-31 |
| A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure Eplerenone, Spironolactone - Systolic Heart Failure | Phase 4 | Enrolling by invitation | Bispebjerg Hospital | 7200 | 2020-11-01 | 2023-02-01 |
| Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy Catheter ablation of ventricular arrhythmia, Intensified medical therapy - Systolic Heart Failure, Ventricular Premature Complexes | Completed | Universitätsklinikum Köln | 65 | 2020-09-01 | 2021-11-15 | |
| Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure Ferric carboxymaltose - Cardiac Failure, Systolic Heart Failure | Phase 4 | Unknown | Hospital Moinhos de Vento | 20 | 2019-08-30 | 2019-07-12 |
| How is COGNItive Function Affected by Cardiac Resynchronisation Therapy? Repeatable Assessment of Neuropsychological Status, Hospital Anxiety and Depression Scale, Frontal Assessment Battery - Cognitive Impairment, Cognitive Change | Suspended | Royal Cornwall Hospitals Trust | 198 | 2019-06-21 | 2022-08-02 | |
| Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI) Blood Collection, Blood Volume Analysis - Heart Failure, Volume Overload | Not applicable | Completed | Mayo Clinic | 20 | 2019-06-11 | 2022-08-23 |
| ECG for Programming in CRT Programming individualized RV-LV pacing offset to optimize ECG, Nominally programming CRT device without RV-LV offset - Systolic Heart Failure, Cardiac Resynchronization Therapy | Not applicable | Terminated | Washington University School of Medicine | 4 | 2019-04-22 | 2020-12-03 |
| Iron in Patients With Cardiovascular Disease Ferric carboxymaltose, Saline - Cardiovascular Diseases, Anemia, Iron-deficiency | Phase 3 | Terminated | Dr. med. Mahir Karakas | 8 | 2019-02-28 | 2023-12-27 |
| Effectiveness of a Repetitive Use of 24-hour Levosimendan Infusions in Patients With Severe Systolic Heart Failure in Order to Prevent Rehospitalizations Levosimendan - Systolic Heart Failure | Phase 4 | Unknown | Collegium Medicum w Bydgoszczy | 100 | 2018-08-01 | 2018-12-05 |
| Pedometer-Based Walking Intervention in Patients With Chronic Heart Failure With Reduced Ejection Fraction Walking intervention - Systolic Heart Failure | Not applicable | Unknown | Charles University, Czech Republic | 202 | 2018-08-01 | 2023-10-04 |
| Study of Dapansutrile Capsules in Heart Failure dapansutrile capsules, Placebo capsules - Systolic Heart Failure | Phase 1 | Completed | Olatec Therapeutics, Inc. | 30 | 2018-05-16 | 2020-01-09 |
| Technology-Based Intervention to Promote Heart Health After Cardiac Rehab (Mobile4Heart) Movn Mobile App - Ischemic Heart Disease, Unstable Angina | Not applicable | Completed | University of California, San Francisco | 60 | 2018-02-28 | 2025-04-10 |
| Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality Iron, Saline - Systolic Heart Failure, Iron Deficiency | Phase 4 | Completed | Universitätsklinikum Hamburg-Eppendorf | 1105 | 2017-03-07 | 2025-01-28 |
| My Research Legacy Pilot Study Myocardial Infarction, Stroke | Terminated | American Heart Association | 2267 | 2016-11-11 | 2021-03-08 | |
| Junctional AV Ablation in CRT-D: JAVA-CRT Atrioventricular junctional (AVJ) ablation, Cardiac resynchronization therapy - defibrillator - Systolic Heart Failure, Atrial Fibrillation (Permanent) | Not applicable | Completed | University of Rochester | 26 | 2016-10-01 | 2022-01-25 |
| GutHeart: Targeting Gut Microbiota to Treat Heart Failure Rifaximin, Saccharomyces boulardii - Systolic Heart Failure | Phase 2 | Unknown | Oslo University Hospital | 150 | 2016-03-11 | 2019-03-26 |
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Heart Failure, Systolic (46) · Heart Failure (23) · Heart Failure, Diastolic (6) · Atrial Fibrillation (4) · Cardiomyopathies (3) · Ventricular Dysfunction, Left (3) · Cardiovascular Diseases (2) · Depression (2) · Iron Deficiencies (2) · Tachycardia, Ventricular (2) · Ventricular Premature Complexes (2) · Acute Coronary Syndrome (1) · Anemia (1) · Anemia, Iron-Deficiency (1) · Angina, Unstable (1)
Heart Diseases (45) · Cardiovascular Diseases (44) · Heart Failure (23) · Pathological Conditions, Signs and Symptoms (14) · Pathologic Processes (11) · Arrhythmias, Cardiac (7) · Cardiac Conduction System Disease (4) · Signs and Symptoms (4) · Behavior (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Vascular Diseases (3) · Ventricular Dysfunction (3) · Behavioral Symptoms (2) · Brain Diseases (2)
Sodium Chloride (2) · ferric carboxymaltose (2) · Blood Specimen Collection (1) · Cardiac Rehabilitation (1) · Clopidogrel (1) · Eplerenone (1) · Exercise (1) · Iron (1) · Methods (1) · Prasugrel Hydrochloride (1) · Rifaximin (1) · Simendan (1) · Spironolactone (1) · Verapamil (1) · dapansutrile (1)
Noblewell (2) · Abbott Medical Devices (1) · Alere San Diego (1) · American Heart Association (1) · Assistance Publique - Hôpitaux de Paris (1) · Bispebjerg Hospital (1) · Brooke Army Medical Center (1) · CES University (1) · Charles University, Czech Republic (1) · Collegium Medicum w Bydgoszczy (1) · Dr. med. Mahir Karakas (1) · Giresun University (1) · Guidant Corporation (1) · Hospital Moinhos de Vento (1) · Libin Cardiovascular Institute of Alberta (1)
United States (16) · Poland (5) · Germany (4) · United Kingdom (4) · Sweden (3) · Australia (2) · Brazil (2) · Canada (2) · France (2) · India (2) · Netherlands (2) · Spain (2) · Belgium (1) · Colombia (1) · Czechia (1)
Ajit Singh, PHARM D, PhD (1) · Amit Noheria, MBBS, SM (1) · Carisi A Polanczyk, MD ScD (1) · Cecilia Linde, MD PhD (1) · Christophe Leclercq, MD (1) · Daniel D Matlock, MD, MPH (1) · David Pereg, MD (1) · Donny R. Stokes, M.D. (1) · Edimar A Bocchi, MD (1) · Elliott Miller, MD, MS (1) · Faiez Zannad, Professor (1) · Franz Kleber, Professor (1) · Gordon R Reeves, MD, MPT (1)
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R21AG075639 (1)