11 completed, 11 unknown, 5 not yet recruiting, 2 active not recruiting. 12 Not applicable, 2 Phase 2, 2 Phase 3, 2 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 7, Unknown 3, Not yet recruiting 2 |
| Phase 2 | 2 | Suspended 1, Terminated 1 |
| Phase 3 | 2 | Suspended 1, Terminated 1 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
Follow Severe Pneumonia: new trials by email Literature Review of Severe Pneumonia trials Research Report on Severe Pneumonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Feasibility and Preliminary Efficacy of a Child Life-Based Breathing Exercise Program for Children Recovering From Severe Pneumonia: A Pilot Randomized Controlled Trial routine health education + a Child Life-Based Breathing Exercise Program, routine health education - Severe Pneumonia | Not applicable | Not yet recruiting | Children's Hospital of Fudan University | 30 | 2026-06-01 | 2026-05-18 |
| Rapid Identification of Infectious Pathogens in Severe Pneumonia Guided by Bronchoscopic Imaging and Lung CT Standalone Lung CT for Severe Pneumonia Diagnosis, Bronchoscopic Imaging + Lung CT for Severe Pneumonia diagnosis - Severe Pneumonia | Not yet recruiting | The First Hospital of Jilin University | 400 | 2026-05-01 | 2026-02-09 | |
| A Prospective Observational Cohort Study Protocol for Disease Severity Stratification and Prognosis Assessment in Patients With Pneumonia Severe Pneumonia, Pneumonia | Not yet recruiting | Zhonghao Fang | 2700 | 2026-05-01 | 2026-05-05 | |
| Impact of a High-Protein Diet on Clinical Outcomes in Mechanically Ventilated Patients With Severe Pneumonia Mechanically Ventilated Patients, Severe Pneumonia | Active not recruiting | Fayoum University | 60 | 2025-10-09 | 2026-06-08 | |
| AI-Driven Accurate Diagnosis of Pathogens in Severe Pneumonia Severe Pneumonia | Active not recruiting | Guangzhou Medical University | 1000 | 2025-09-18 | 2026-03-12 | |
| Diagnostic Application of AI-ROSE in Severe Pneumonia Severe Pneumonia, Bacterial Infections | Enrolling by invitation | The First Affiliated Hospital with Nanjing Medical University | 100 | 2025-08-31 | 2025-08-11 | |
| Herpes Simplex Virus Type 1 Infection/Reactivation of Patients With Severe Pneumonia（the HSV-SP Study） Bronchoalveolar Lavage (BAL) via Fiberoptic Bronchoscopy, throat Swab - Severe Pneumonia | Not yet recruiting | Second Affiliated Hospital of Guangzhou Medical University | 323 | 2025-06-01 | 2025-04-25 | |
| Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania Rhapsode Capable™ Platform (Intervention Group), Paper-based ISP (Control Group) - Newborn Resuscitation, Severe Malnutrition | Not applicable | Not yet recruiting | Stanford University | 100 | 2025-01-06 | 2024-10-10 |
| Species-specific Bacterial Detector for Fast Pathogen Diagnosis of Severe Pneumonia results of SSBD are used to guide antibiotics adjustment - Severe Pneumonia | Not applicable | Unknown | Chinese Medical Association | 256 | 2024-11-01 | 2024-10-26 |
| Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Diagnosis Severe Pneumonia, Biomarkers | Unknown | Chinese PLA General Hospital | 100 | 2024-09-01 | 2024-08-01 | |
| Dynamic Pattern of Etiology, Immunoinflammatory Factors and Their Association With Prognosis of Severe Pneumonia Severe Pneumonia | Unknown | Shanghai General Hospital, China | 600 | 2024-08-01 | 2024-08-07 | |
| Fiberoptic Bronchoscopy in Severe Ventilator-associated Pneumonia Other (Conventional Therapy), Fiberoptic Bronchoscopy - Ventilator-Associated Pneumonia, Severe Pneumonia | Not applicable | Completed | Benha University | 100 | 2023-12-15 | 2025-09-02 |
| Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study Metagenomics - Severe Pneumonia | Recruiting | First Affiliated Hospital of Zhejiang University | 2000 | 2023-09-25 | 2025-08-07 | |
| Research on the Treatment of Severe Community-acquired Pneumonia in Children Prednisolone Acetate, placebo - Severe Pneumonia | Phase 4 | Unknown | Baoping XU | 160 | 2023-03-10 | 2023-03-14 |
| The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia Severe Pneumonia | Completed | Xiangya Hospital of Central South University | 260 | 2023-02-01 | 2026-09-21 | |
| Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Patients Ambroxol Hydrochloride, Standard Therapy - Severe Pneumonia, Community-acquired Pneumonia | Phase 4 | Completed | National University of Malaysia | 32 | 2023-01-07 | 2023-12-27 |
| Lung Response to a Higher PEEP During Severe Pneumonia: a CT Study Severe Pneumonia | Completed | Istituto Clinico Humanitas | 47 | 2022-10-01 | 2025-08-13 | |
| Yinhu Qingwen Granula for the Treatment of Severe CoVID-19 Yinhu Qingwen Granula, Yin Hu Qing Wen Granula(low does), standard medical treatment - COVID-19, Severe Pneumonia | Phase 2 / Phase 3 | Suspended | Zhong Wang | 116 | 2021-11-01 | 2021-07-07 |
| Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Made bCPAP: Feasibility Study Adult bubble CPAP oxygen therapy device - Severe Pneumonia, Acute Respiratory Distress Syndrome | Not applicable | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 20 | 2021-10-08 | 2022-08-25 |
| Early Identification and Severity Prediction of Acute Respiratory Infectious Disease mNGS, Multiplex PCR - Acute Respiratory Infection, Severe Pneumonia | Not applicable | Unknown | Huashan Hospital | 440 | 2021-04-04 | 2022-05-12 |
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Pneumonia (34) · COVID-19 (5) · Disease (3) · Respiratory Distress Syndrome (3) · Community-Acquired Pneumonia (2) · Critical Illness (2) · Hypoxia (2) · Bacterial Infections (1) · Cephalopelvic Disproportion (1) · Child Nutrition Disorders (1) · Dehydration (1) · Disease Progression (1) · Healthcare-Associated Pneumonia (1) · Latent Infection (1) · Malaria (1)
Infections (34) · Lung Diseases (34) · Respiratory Tract Diseases (34) · Respiratory Tract Infections (33) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (9) · Virus Diseases (6) · Coronaviridae Infections (5) · Coronavirus Infections (5) · Nidovirales Infections (5) · Pneumonia, Viral (5) · RNA Virus Infections (5) · Respiration Disorders (4) · Disease Attributes (3) · Bacterial Infections and Mycoses (2)
Standard of Care (2) · Ambroxol (1) · Amoxicillin (1) · Control Groups (1) · Oximetry (1) · Prednisolone (1) · Prone Position (1) · prednisolone acetate (1) · reparixin (1) · tocilizumab (1)
International Centre for Diarrhoeal Disease Research, Bangladesh (3) · Aga Khan University (2) · Xiangya Hospital of Central South University (2) · Asan Medical Center (1) · Baoping XU (1) · Benha University (1) · Children's Hospital of Fudan University (1) · Chinese Medical Association (1) · Chinese PLA General Hospital (1) · Consorcio Centro de Investigación Biomédica en Red (CIBER) (1) · Dompé Farmaceutici S.p.A (1) · Fayoum University (1) · First Affiliated Hospital of Zhejiang University (1) · Guangzhou Medical University (1) · Huashan Hospital (1)
China (13) · Bangladesh (3) · Italy (3) · Egypt (2) · Pakistan (2) · Brazil (1) · Cambodia (1) · Cameroon (1) · Croatia (1) · Côte d’Ivoire (1) · Malaysia (1) · Mozambique (1) · South Korea (1) · Spain (1) · Tanzania (1)
Adolfine Hokororo, MD (1) · Alberto Zangrillo, MD PhD (1) · Antoni Torres, PhD (1) · Baoping Xu (1) · Dong Shang, M.D. (1) · Eric Wobudeya, MD, PhD (1) · Fatima Mir, FCPS (1) · Hasan Ashraf, MD (1) · Jiang-Rong Huang, M.D. (1) · Jieming Qu, MD,PhD (1) · Lingtong Huang, M.D. (1) · Lorenzo Piemonti, MD PhD (1) · Maryline Bonnet, MD, PhD (1)
PMID 20855397, PMID 22285055, PMID 22842561, PMID 26296950, PMID 32853411, PMID 33743621, PMID 34535473, PMID 35603455, PMID 35618953, PMID 35858876, PMID 36395782, PMID 36579494, PMID 38522443, PMID 39814268, PMID 41189033, PMID 41759657, PMID 42829580
R21TW012612 (1)