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Most Influential ICML 2017 Paper · 2026-03 edition

Learning Important Features Through Propagating Activation Differences

Avanti Shrikumar; Peyton Greenside; Anshul Kundaje

Venue
International Conference on Machine Learning (ICML) 2017
Recognition
Most Influential ICML 2017 Paper (Rank No. 6)
Edition
2026-03
Impact factor
9
Certificate ID
766c51b26b1b9054

Abstract

The purported “black box” nature of neural networks is a barrier to adoption in applications where interpretability is essential. Here we present DeepLIFT (Deep Learning Important FeaTures), a method for decomposing the output prediction of a neural network on a specific input by backpropagating the contributions of all neurons in the network to every feature of the input. DeepLIFT compares the activation of each neuron to its `reference activation’ and assigns contribution scores according to the difference. By optionally giving separate consideration to positive and negative contributions, DeepLIFT can also reveal dependencies which are missed by other approaches. Scores can be computed efficiently in a single backward pass. We apply DeepLIFT to models trained on MNIST and simulated genomic data, and show significant advantages over gradient-based methods. Video tutorial: http://goo.gl/qKb7pL code: http://goo.gl/RM8jvH

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