Most Influential SCIENCE Papers
Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world’s top academic journals. Paper Digest Team analyze all papers published on SCIENCE in the past years, and presents the 10 most influential papers for each year. This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences, please visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards.
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Paper Digest Team
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TABLE 1: Most Influential SCIENCE Papers
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2020 | 1 | Substantial Undocumented Infection Facilitates The Rapid Dissemination of Novel Coronavirus (SARS-CoV-2) IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Estimation of the prevalence and contagiousness of undocumented novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] infections is critical for … |
RUIYUN LI et. al. |
| 2020 | 2 | Structural Basis For The Recognition Of SARS-CoV-2 By Full-length Human ACE2 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing … |
RENHONG YAN et. al. |
| 2020 | 3 | Projecting The Transmission Dynamics of SARS-CoV-2 Through The Postpandemic Period IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: It is urgent to understand the future of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) transmission. We used estimates of seasonality, immunity, and cross-immunity … |
Stephen M Kissler; Christine Tedijanto; Edward Goldstein; Yonatan H Grad; Marc Lipsitch; |
| 2020 | 4 | The Effect Of Travel Restrictions On The Spread Of The 2019 Novel Coronavirus (COVID-19) Outbreak IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Motivated by the rapid spread of coronavirus disease 2019 (COVID-19) in mainland China, we use a global metapopulation disease transmission model to project the impact of travel … |
MATTEO CHINAZZI et. al. |
| 2020 | 5 | Quantifying SARS-CoV-2 Transmission Suggests Epidemic Control with Digital Contact Tracing IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The newly emergent human virus SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) is resulting in high fatality rates and incapacitated health systems. Preventing … |
LUCA FERRETTI et. al. |
| 2020 | 6 | The Effect Of Human Mobility And Control Measures On The COVID-19 Epidemic In China IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The ongoing coronavirus disease 2019 (COVID-19) outbreak expanded rapidly throughout China. Major behavioral, clinical, and state interventions were undertaken to mitigate the … |
MORITZ U G KRAEMER et. al. |
| 2020 | 7 | Structure of The RNA-dependent RNA Polymerase from COVID-19 Virus IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] outbreak has caused a global coronavirus disease 2019 (COVID-19) pandemic, resulting in tens of … |
YAN GAO et. al. |
| 2020 | 8 | Cytokine Release Syndrome In Severe COVID-19 IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
John B Moore; Carl H June; |
| 2020 | 9 | An Investigation Of Transmission Control Measures During The First 50 Days Of The COVID-19 Epidemic In China IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Responding to an outbreak of a novel coronavirus [agent of coronavirus disease 2019 (COVID-19)] in December 2019, China banned travel to and from Wuhan city on 23 January 2020 and … |
HUAIYU TIAN et. al. |
| 2020 | 10 | Development of An Inactivated Vaccine Candidate for SARS-CoV-2 IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. … |
QIANG GAO et. al. |
| 2019 | 1 | Language And The Brain IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Lera Boroditsky; |
| 2019 | 2 | Tuning Superconductivity In Twisted Bilayer Graphene IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Materials with flat electronic bands often exhibit exotic quantum phenomena owing to strong correlations. An isolated low-energy flat band can be induced in bilayer graphene by … |
MATTHEW YANKOWITZ et. al. |
| 2019 | 3 | Emergent Ferromagnetism Near Three-quarters Filling In Twisted Bilayer Graphene IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: When two sheets of graphene are stacked at a small twist angle, the resulting flat superlattice minibands are expected to strongly enhance electron-electron interactions. Here, we … |
AARON L SHARPE et. al. |
| 2019 | 4 | Slide-seq: A Scalable Technology For Measuring Genome-wide Expression At High Spatial Resolution IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Spatial positions of cells in tissues strongly influence function, yet a high-throughput, genome-wide readout of gene expression with cellular resolution is lacking. We developed … |
SAMUEL G RODRIQUES et. al. |
| 2019 | 5 | The Global Tree Restoration Potential IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The restoration of trees remains among the most effective strategies for climate change mitigation. We mapped the global potential tree coverage to show that 4.4 billion hectares … |
JEAN-FRANCOIS BASTIN et. al. |
| 2019 | 6 | Exceptional Points In Optics And Photonics IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Exceptional points are branch point singularities in the parameter space of a system at which two or more eigenvalues, and their corresponding eigenvectors, coalesce and become … |
Mohammad-Ali Miri; Andrea Alù; |
| 2019 | 7 | Dissecting Racial Bias in An Algorithm Used to Manage The Health of Populations IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Health systems rely on commercial prediction algorithms to identify and help patients with complex health needs. We show that a widely used algorithm, typical of this … |
Ziad Obermeyer; Brian Powers; Christine Vogeli; Sendhil Mullainathan; |
| 2019 | 8 | Spontaneous Behaviors Drive Multidimensional, Brainwide Activity IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Neuronal populations in sensory cortex produce variable responses to sensory stimuli and exhibit intricate spontaneous activity even without external sensory input. Cortical … |
CARSEN STRINGER et. al. |
| 2019 | 9 | Cytosine Base Editor Generates Substantial Off-target Single-nucleotide Variants in Mouse Embryos IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genome editing holds promise for correcting pathogenic mutations. However, it is difficult to determine off-target effects of editing due to single-nucleotide polymorphism in … |
ERWEI ZUO et. al. |
| 2019 | 10 | Two-dimensional Magnetic Crystals And Emergent Heterostructure Devices IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Magnetism, originating from the moving charges and spin of elementary particles, has revolutionized important technologies such as data storage and biomedical imaging, and … |
Cheng Gong; Xiang Zhang; |
| 2018 | 1 | Cancer Immunotherapy Using Checkpoint Blockade IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses in … |
Antoni Ribas; Jedd D Wolchok; |
| 2018 | 2 | Organic And Solution-processed Tandem Solar Cells With 17.3% Efficiency IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although organic photovoltaic (OPV) cells have many advantages, their performance still lags far behind that of other photovoltaic platforms. A fundamental reason for their low … |
LINGXIAN MENG et. al. |
| 2018 | 3 | Detection and Localization of Surgically Resectable Cancers with A Multi-analyte Blood Test IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating … |
JOSHUA D COHEN et. al. |
| 2018 | 4 | Shifting The Limits In Wheat Research And Breeding Using A Fully Annotated Reference Genome IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding … |
et. al. |
| 2018 | 5 | The Science Of Fake News IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
DAVID M J LAZER et. al. |
| 2018 | 6 | A General Reinforcement Learning Algorithm That Masters Chess, Shogi, And Go Through Self-play IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The game of chess is the longest-studied domain in the history of artificial intelligence. The strongest programs are based on a combination of sophisticated search techniques, … |
DAVID SILVER et. al. |
| 2018 | 7 | CAR T Cell Immunotherapy For Human Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field … |
Carl H June; Roddy S O’Connor; Omkar U Kawalekar; Saba Ghassemi; Michael C Milone; |
| 2018 | 8 | Assessing Nature’s Contributions To People IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
SANDRA DÍAZ et. al. |
| 2018 | 9 | Declining Oxygen In The Global Ocean And Coastal Waters IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Oxygen is fundamental to life. Not only is it essential for the survival of individual animals, but it regulates global cycles of major nutrients and carbon. The oxygen content of … |
DENISE BREITBURG et. al. |
| 2018 | 10 | Coactivator Condensation At Super-enhancers Links Phase Separation And Gene Control IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent … |
BENJAMIN R SABARI et. al. |
| 2017 | 1 | Mismatch Repair Deficiency Predicts Response Of Solid Tumors To PD-1 Blockade IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal … |
DUNG T LE et. al. |
| 2017 | 2 | Efficient And Stable Solution-processed Planar Perovskite Solar Cells Via Contact Passivation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Planar perovskite solar cells (PSCs) made entirely via solution processing at low temperatures (<150°C) offer promise for simple manufacturing, compatibility with flexible ... |
HAIREN TAN et. al. |
| 2017 | 3 | Combining Theory And Experiment In Electrocatalysis: Insights Into Materials Design IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Electrocatalysis plays a central role in clean energy conversion, enabling a number of sustainable processes for future technologies. This review discusses design strategies for … |
ZHI WEI SEH et. al. |
| 2017 | 4 | The Spread Of True And False News Online IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We investigated the differential diffusion of all of the verified true and false news stories distributed on Twitter from 2006 to 2017. The data comprise ~126,000 stories tweeted … |
Soroush Vosoughi; Deb Roy; Sinan Aral; |
| 2017 | 5 | A Pathology Atlas Of The Human Cancer Transcriptome IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of … |
MATHIAS UHLEN et. al. |
| 2017 | 6 | Liquid Phase Condensation In Cell Physiology And Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Phase transitions are ubiquitous in nonliving matter, and recent discoveries have shown that they also play a key role within living cells. Intracellular liquid-liquid phase … |
Yongdae Shin; Clifford P Brangwynne; |
| 2017 | 7 | Biodiversity Redistribution Under Climate Change: Impacts On Ecosystems And Human Well-being IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Distributions of Earth’s species are changing at accelerating rates, increasingly driven by human-mediated climate change. Such changes are already altering the composition of … |
GRETTA T PECL et. al. |
| 2017 | 8 | Nucleic Acid Detection With CRISPR-Cas13a/C2c2 IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered … |
JONATHAN S GOOTENBERG et. al. |
| 2017 | 9 | Gut Bacteria Selectively Promoted By Dietary Fibers Alleviate Type 2 Diabetes IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 … |
LIPING ZHAO et. al. |
| 2017 | 10 | PARP Inhibitors: Synthetic Lethality In The Clinic IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept … |
Christopher J Lord; Alan Ashworth; |
| 2016 | 1 | Metalenses At Visible Wavelengths: Diffraction-limited Focusing And Subwavelength Resolution Imaging IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Subwavelength resolution imaging requires high numerical aperture (NA) lenses, which are bulky and expensive. Metasurfaces allow the miniaturization of conventional refractive … |
MOHAMMADREZA KHORASANINEJAD et. al. |
| 2016 | 2 | A Mixed-cation Lead Mixed-halide Perovskite Absorber For Tandem Solar Cells IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metal halide perovskite photovoltaic cells could potentially boost the efficiency of commercial silicon photovoltaic modules from ∼20 toward 30% when used in tandem architectures. … |
DAVID P MCMEEKIN et. al. |
| 2016 | 3 | Clonal Neoantigens Elicit T Cell Immunoreactivity And Sensitivity To Immune Checkpoint Blockade IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of … |
NICHOLAS MCGRANAHAN et. al. |
| 2016 | 4 | Electromagnetic Interference Shielding With 2D Transition Metal Carbides (MXenes) IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Materials with good flexibility and high conductivity that can provide electromagnetic interference (EMI) shielding with minimal thickness are highly desirable, especially if they … |
FAISAL SHAHZAD et. al. |
| 2016 | 5 | Optically Resonant Dielectric Nanostructures IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Rapid progress in nanophotonics is driven by the ability of optically resonant nanostructures to enhance near-field effects controlling far-field scattering through intermodal … |
Arseniy I Kuznetsov; Andrey E Miroshnichenko; Mark L Brongersma; Yuri S Kivshar; Boris Luk’yanchuk; |
| 2016 | 6 | Incorporation Of Rubidium Cations Into Perovskite Solar Cells Improves Photovoltaic Performance IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: All of the cations currently used in perovskite solar cells abide by the tolerance factor for incorporation into the lattice. We show that the small and oxidation-stable rubidium … |
MICHAEL SALIBA et. al. |
| 2016 | 7 | Active Sites Of Nitrogen-doped Carbon Materials For Oxygen Reduction Reaction Clarified Using Model Catalysts IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nitrogen (N)-doped carbon materials exhibit high electrocatalytic activity for the oxygen reduction reaction (ORR), which is essential for several renewable energy systems. … |
DONGHUI GUO et. al. |
| 2016 | 8 | Complement And Microglia Mediate Early Synapse Loss In Alzheimer Mouse Models IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Synapse loss in Alzheimer’s disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late … |
SOYON HONG et. al. |
| 2016 | 9 | Homogeneously Dispersed Multimetal Oxygen-evolving Catalysts IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Earth-abundant first-row (3d) transition metal-based catalysts have been developed for the oxygen-evolution reaction (OER); however, they operate at overpotentials substantially … |
BO ZHANG et. al. |
| 2016 | 10 | C2c2 Is A Single-component Programmable RNA-guided RNA-targeting CRISPR Effector IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign genetic elements via … |
OMAR O ABUDAYYEH et. al. |
| 2015 | 1 | Rationally Engineered Cas9 Nucleases With Improved Specificity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes. Cas9 creates … |
IAN M SLAYMAKER et. al. |
| 2015 | 2 | Adoptive Cell Transfer As Personalized Immunotherapy For Human Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT … |
Steven A Rosenberg; Nicholas P Restifo; |
| 2015 | 3 | Neoantigens In Cancer Immunotherapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to … |
Ton N Schumacher; Robert D Schreiber; |
| 2015 | 4 | The Future Of Immune Checkpoint Therapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses, has led to important clinical advances and provided a new weapon … |
Padmanee Sharma; James P Allison; |
| 2015 | 5 | Genomic Correlates Of Response To CTLA-4 Blockade In Metastatic Melanoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Monoclonal antibodies directed against cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for patients with metastatic … |
ELIEZER M VAN ALLEN et. al. |
| 2015 | 6 | Anticancer Immunotherapy By CTLA-4 Blockade Relies On The Gut Microbiota IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In … |
MARIE VÉTIZOU et. al. |
| 2015 | 7 | Human-level Concept Learning Through Probabilistic Program Induction IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: People learning new concepts can often generalize successfully from just a single example, yet machine learning algorithms typically require tens or hundreds of examples to … |
Brenden M Lake; Ruslan Salakhutdinov; Joshua B Tenenbaum; |
| 2015 | 8 | Dissecting The Multicellular Ecosystem Of Metastatic Melanoma By Single-cell RNA-seq IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, … |
ITAY TIROSH et. al. |
| 2015 | 9 | Bee Declines Driven By Combined Stress From Parasites, Pesticides, And Lack Of Flowers IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bees are subject to numerous pressures in the modern world. The abundance and diversity of flowers has declined; bees are chronically exposed to cocktails of agrochemicals, and … |
Dave Goulson; Elizabeth Nicholls; Cristina Botías; Ellen L Rotheray; |
| 2015 | 10 | Efficient And Stable Large-area Perovskite Solar Cells With Inorganic Charge Extraction Layers IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The recent dramatic rise in power conversion efficiencies (PCEs) of perovskite solar cells (PSCs) has triggered intense research worldwide. However, high PCE values have often … |
WEI CHEN et. al. |
| 2014 | 1 | Single-cell RNA-seq Highlights Intratumoral Heterogeneity In Primary Glioblastoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor composition … |
ANOOP P PATEL et. al. |
| 2014 | 2 | Precise And Ultrafast Molecular Sieving Through Graphene Oxide Membranes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Graphene-based materials can have well-defined nanometer pores and can exhibit low frictional water flow inside them, making their properties of interest for filtration and … |
R K JOSHI et. al. |
| 2014 | 3 | Dielectric Gradient Metasurface Optical Elements IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gradient metasurfaces are two-dimensional optical elements capable of manipulating light by imparting local, space-variant phase changes on an incident electromagnetic wave. These … |
Dianmin Lin; Pengyu Fan; Erez Hasman; Mark L Brongersma; |
| 2014 | 4 | Lignin Valorization: Improving Lignin Processing In The Biorefinery IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Research and development activities directed toward commercial production of cellulosic ethanol have created the opportunity to dramatically increase the transformation of lignin … |
ARTHUR J RAGAUSKAS et. al. |
| 2014 | 5 | Highly Crystalline Multimetallic Nanoframes With Three-dimensional Electrocatalytic Surfaces IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Control of structure at the atomic level can precisely and effectively tune catalytic properties of materials, enabling enhancement in both activity and durability. We synthesized … |
CHEN CHEN et. al. |
| 2014 | 6 | Nanoporous BiVO4 Photoanodes With Dual-layer Oxygen Evolution Catalysts For Solar Water Splitting IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bismuth vanadate (BiVO4) has a band structure that is well-suited for potential use as a photoanode in solar water splitting, but it suffers from poor electron-hole separation. … |
Tae Woo Kim; Kyoung-Shin Choi; |
| 2014 | 7 | Massively Parallel Single-cell RNA-seq For Marker-free Decomposition Of Tissues Into Cell Types IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In multicellular organisms, biological function emerges when heterogeneous cell types form complex organs. Nevertheless, dissection of tissues into mixtures of cellular … |
DIEGO ADHEMAR JAITIN et. al. |
| 2014 | 8 | Organogenesis In A Dish: Modeling Development And Disease Using Organoid Technologies IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Classical experiments performed half a century ago demonstrated the immense self-organizing capacity of vertebrate cells. Even after complete dissociation, cells can reaggregate … |
Madeline A Lancaster; Juergen A Knoblich; |
| 2014 | 9 | Lattice Light-sheet Microscopy: Imaging Molecules To Embryos At High Spatiotemporal Resolution IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although fluorescence microscopy provides a crucial window into the physiology of living specimens, many biological processes are too fragile, are too small, or occur too rapidly … |
BI-CHANG CHEN et. al. |
| 2014 | 10 | A Fracture-resistant High-entropy Alloy For Cryogenic Applications IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: High-entropy alloys are equiatomic, multi-element systems that can crystallize as a single phase, despite containing multiple elements with different crystal structures. A … |
BERND GLUDOVATZ et. al. |
| 2013 | 1 | Multiplex Genome Engineering Using CRISPR/Cas Systems IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short … |
LE CONG et. al. |
| 2013 | 2 | RNA-guided Human Genome Engineering Via Cas9 IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use … |
PRASHANT MALI et. al. |
| 2013 | 3 | Genome-scale CRISPR-Cas9 Knockout Screening In Human Cells IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease Cas9 to modify specific genomic loci suggests a new way to … |
OPHIR SHALEM et. al. |
| 2013 | 4 | Cancer Genome Landscapes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a … |
BERT VOGELSTEIN et. al. |
| 2013 | 5 | Genetic Screens In Human Cells Using The CRISPR-Cas9 System IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, enabling … |
Tim Wang; Jenny J Wei; David M Sabatini; Eric S Lander; |
| 2013 | 6 | The Chemistry And Applications Of Metal-organic Frameworks IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Crystalline metal-organic frameworks (MOFs) are formed by reticular synthesis, which creates strong bonds between inorganic and organic units. Careful selection of MOF … |
Hiroyasu Furukawa; Kyle E Cordova; Michael O’Keeffe; Omar M Yaghi; |
| 2013 | 7 | Gut Microbiota From Twins Discordant For Obesity Modulate Metabolism In Mice IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free … |
VANESSA K RIDAURA et. al. |
| 2013 | 8 | Planar Photonics With Metasurfaces IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metamaterials, or engineered materials with rationally designed, subwavelength-scale building blocks, allow us to control the behavior of physical fields in optical, microwave, … |
Alexander V Kildishev; Alexandra Boltasseva; Vladimir M Shalaev; |
| 2013 | 9 | Superconducting Circuits For Quantum Information: An Outlook IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The performance of superconducting qubits has improved by several orders of magnitude in the past decade. These circuits benefit from the robustness of superconductivity and the … |
M H Devoret; R J Schoelkopf; |
| 2013 | 10 | Electron-hole Diffusion Lengths Exceeding 1 Micrometer In An Organometal Trihalide Perovskite Absorber IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Organic-inorganic perovskites have shown promise as high-performance absorbers in solar cells, first as a coating on a mesoporous metal oxide scaffold and more recently as a solid … |
SAMUEL D STRANKS et. al. |
| 2012 | 1 | Spin-torque Switching With The Giant Spin Hall Effect Of Tantalum IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Spin currents can apply useful torques in spintronic devices. The spin Hall effect has been proposed as a source of spin current, but its modest strength has limited its … |
LUQIAO LIU et. al. |
| 2012 | 2 | Efficient Hybrid Solar Cells Based On Meso-superstructured Organometal Halide Perovskites IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The energy costs associated with separating tightly bound excitons (photoinduced electron-hole pairs) and extracting free charges from highly disordered low-mobility networks … |
Michael M Lee; Joël Teuscher; Tsutomu Miyasaka; Takurou N Murakami; Henry J Snaith; |
| 2012 | 3 | Laser Scribing Of High-performance And Flexible Graphene-based Electrochemical Capacitors IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although electrochemical capacitors (ECs), also known as supercapacitors or ultracapacitors, charge and discharge faster than batteries, they are still limited by low energy … |
Maher F El-Kady; Veronica Strong; Sergey Dubin; Richard B Kaner; |
| 2012 | 4 | Photoacoustic Tomography: In Vivo Imaging From Organelles To Organs IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Photoacoustic tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs. This emerging technology overcomes the … |
Lihong V Wang; Song Hu; |
| 2012 | 5 | Interactions Between The Microbiota And The Immune System IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these microbes carry out … |
Lora V Hooper; Dan R Littman; Andrew J Macpherson; |
| 2012 | 6 | Cyclic GMP-AMP Synthase Is A Cytosolic DNA Sensor That Activates The Type I Interferon Pathway IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces … |
Lijun Sun; Jiaxi Wu; Fenghe Du; Xiang Chen; Zhijian J Chen; |
| 2012 | 7 | Large-pore Apertures In A Series Of Metal-organic Frameworks IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We report a strategy to expand the pore aperture of metal-organic frameworks (MOFs) into a previously unattained size regime (>32 angstroms). Specifically, the systematic … |
HEXIANG DENG et. al. |
| 2012 | 8 | Signatures Of Majorana Fermions In Hybrid Superconductor-semiconductor Nanowire Devices IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Majorana fermions are particles identical to their own antiparticles. They have been theoretically predicted to exist in topological superconductors. Here, we report electrical … |
V MOURIK et. al. |
| 2012 | 9 | A Reversible And Higher-rate Li-O2 Battery IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The rechargeable nonaqueous lithium-air (Li-O(2)) battery is receiving a great deal of interest because, theoretically, its specific energy far exceeds the best that can be … |
Zhangquan Peng; Stefan A Freunberger; Yuhui Chen; Peter G Bruce; |
| 2012 | 10 | A Logic-gated Nanorobot For Targeted Transport Of Molecular Payloads IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We describe an autonomous DNA nanorobot capable of transporting molecular payloads to cells, sensing cell surface inputs for conditional, triggered activation, and reconfiguring … |
Shawn M Douglas; Ido Bachelet; George M Church; |
| 2011 | 1 | Light Propagation With Phase Discontinuities: Generalized Laws Of Reflection And Refraction IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Conventional optical components rely on gradual phase shifts accumulated during light propagation to shape light beams. New degrees of freedom are attained by introducing abrupt … |
NANFANG YU et. al. |
| 2011 | 2 | Single-cell Mass Cytometry Of Differential Immune And Drug Responses Across A Human Hematopoietic Continuum IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis. We used single-cell mass cytometry to examine healthy human bone marrow, measuring … |
SEAN C BENDALL et. al. |
| 2011 | 3 | Carbon-based Supercapacitors Produced By Activation Of Graphene IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Supercapacitors, also called ultracapacitors or electrochemical capacitors, store electrical charge on high-surface-area conducting materials. Their widespread use is limited by … |
YANWU ZHU et. al. |
| 2011 | 4 | Two-dimensional Nanosheets Produced By Liquid Exfoliation Of Layered Materials IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: If they could be easily exfoliated, layered materials would become a diverse source of two-dimensional crystals whose properties would be useful in applications ranging from … |
JONATHAN N COLEMAN et. al. |
| 2011 | 5 | Tet Proteins Can Convert 5-methylcytosine To 5-formylcytosine And 5-carboxylcytosine IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: 5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable elements. 5mC can be converted to … |
SHINSUKE ITO et. al. |
| 2011 | 6 | Tet-mediated Formation Of 5-carboxylcytosine And Its Excision By TDG In Mammalian DNA IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by the … |
YU-FEI HE et. al. |
| 2011 | 7 | The Ecoresponsive Genome Of Daphnia Pulex IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We describe the draft genome of the microcrustacean Daphnia pulex, which is only 200 megabases and contains at least 30,907 genes. The high gene count is a consequence of an … |
JOHN K COLBOURNE et. al. |
| 2011 | 8 | Electrical Energy Storage For The Grid: A Battery Of Choices IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The increasing interest in energy storage for the grid can be attributed to multiple factors, including the capital costs of managing peak demands, the investments needed for grid … |
Bruce Dunn; Haresh Kamath; Jean-Marie Tarascon; |
| 2011 | 9 | Linking Long-term Dietary Patterns With Gut Microbial Enterotypes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 … |
GARY D WU et. al. |
| 2011 | 10 | The Unfolded Protein Response: From Stress Pathway To Homeostatic Regulation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled … |
Peter Walter; David Ron; |
| 2010 | 1 | CRISPR/Cas, The Immune System Of Bacteria And Archaea IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Microbes rely on diverse defense mechanisms that allow them to withstand viral predation and exposure to invading nucleic acid. In many Bacteria and most Archaea, clustered … |
Philippe Horvath; Rodolphe Barrangou; |
| 2010 | 2 | Induction Of Colonic Regulatory T Cells By Indigenous Clostridium Species IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, … |
KOJI ATARASHI et. al. |
| 2010 | 3 | Creation Of A Bacterial Cell Controlled By A Chemically Synthesized Genome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its … |
DANIEL G GIBSON et. al. |
| 2010 | 4 | Materials And Mechanics For Stretchable Electronics IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with … |
John A Rogers; Takao Someya; Yonggang Huang; |
| 2010 | 5 | Regulation Of Adaptive Immunity By The Innate Immune System IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Twenty years after the proposal that pattern recognition receptors detect invasion by microbial pathogens, the field of immunology has witnessed several discoveries that have … |
Akiko Iwasaki; Ruslan Medzhitov; |
| 2010 | 6 | 100-GHz Transistors From Wafer-scale Epitaxial Graphene IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The high carrier mobility of graphene has been exploited in field-effect transistors that operate at high frequencies. Transistors were fabricated on epitaxial graphene … |
Y-M LIN et. al. |
| 2010 | 7 | Rational Design Of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies To HIV-1 IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1-infected individuals, but the virologic basis of their neutralization remains poorly understood. … |
XUELING WU et. al. |
| 2010 | 8 | Isoprenoid Pathway Optimization For Taxol Precursor Overproduction In Escherichia Coli IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its analogs remains … |
PARAYIL KUMARAN AJIKUMAR et. al. |
| 2010 | 9 | Multiple Functional Groups Of Varying Ratios In Metal-organic Frameworks IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We show that metal-organic frameworks (MOFs) can incorporate a large number of different functionalities on linking groups in a way that mixes the linker, rather than forming … |
HEXIANG DENG et. al. |
| 2010 | 10 | Identification Of A Primary Target Of Thalidomide Teratogenicity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today, thalidomide is still … |
TAKUMI ITO et. al. |