Most Influential NATURE Papers
Nature is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, Nature features peer-reviewed research from a variety of academic disciplines, mainly in science, technology, and the natural sciences. Paper Digest Team analyze all papers published on NATURE in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2021-05-23)
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TABLE 1: Most Influential NATURE Papers
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2020 | 1 | Estimating The Effects of Non-pharmaceutical Interventions on COVID-19 in Europe IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Following the detection of the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its spread outside of China, Europe has experienced large epidemics … |
SETH FLAXMAN et. al. |
| 2020 | 2 | Factors Associated with COVID-19-related Death Using OpenSAFELY IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide . There is unprecedented urgency to understand who is most at risk of severe outcomes, and this … |
ELIZABETH J WILLIAMSON et. al. |
| 2020 | 3 | The Mutational Constraint Spectrum Quantified from Variation in 141,456 Humans IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the … |
KONRAD J KARCZEWSKI et. al. |
| 2020 | 4 | Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people and … |
DAVIDE F ROBBIANI et. al. |
| 2020 | 5 | Human Neutralizing Antibodies Elicited By SARS-CoV-2 Infection IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that is in urgent need … |
BIN JU et. al. |
| 2020 | 6 | SARS-CoV-2-specific T Cell Immunity in Cases of COVID-19 and SARS, and Uninfected Controls IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections . Little is known about the presence in humans of … |
NINA LE BERT et. al. |
| 2020 | 7 | Array Programming with NumPy IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Array programming provides a powerful, compact and expressive syntax for accessing, manipulating and operating on data in vectors, matrices and higher-dimensional arrays. NumPy is … |
CHARLES R HARRIS et. al. |
| 2020 | 8 | A Human Neutralizing Antibody Targets The Receptor-binding Site of SARS-CoV-2 IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: An outbreak of coronavirus disease 2019 (COVID-19) , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) , has spread globally. Countermeasures are needed to … |
RUI SHI et. al. |
| 2020 | 9 | Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19 IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19) . However, the longitudinal immunological correlates of disease outcome remain … |
CAROLINA LUCAS et. al. |
| 2020 | 10 | The Effect Of Large-scale Anti-contagion Policies On The COVID-19 Pandemic IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Governments around the world are responding to the coronavirus disease 2019 (COVID-19) pandemic , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with … |
SOLOMON HSIANG et. al. |
| 2019 | 1 | Quantum Supremacy Using A Programmable Superconducting Processor IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The promise of quantum computers is that certain computational tasks might be executed exponentially faster on a quantum processor than on a classical processor . A fundamental … |
FRANK ARUTE et. al. |
| 2019 | 2 | The Structure of DNA IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Georgina Ferry; |
| 2019 | 3 | Search-and-replace Genome Editing Without Double-strand Breaks Or Donor DNA IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Most genetic variants that contribute to disease are challenging to correct efficiently and without excess byproducts . Here we describe prime editing, a versatile and precise … |
ANDREW V ANZALONE et. al. |
| 2019 | 4 | Grandmaster Level In StarCraft II Using Multi-agent Reinforcement Learning IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Many real-world applications require artificial agents to compete and coordinate with other agents in complex environments. As a stepping stone to this goal, the domain of … |
ORIOL VINYALS et. al. |
| 2019 | 5 | Science And Society IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
ANNA ARMSTRONG et. al. |
| 2019 | 6 | Multi-omics of The Gut Microbial Ecosystem in Inflammatory Bowel Diseases IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, affect several million individuals worldwide. Crohn’s disease and ulcerative colitis are complex … |
JASON LLOYD-PRICE et. al. |
| 2019 | 7 | Conserved Cell Types with Divergent Features in Human Versus Mouse Cortex IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus … |
REBECCA D HODGE et. al. |
| 2019 | 8 | Superconductors, Orbital Magnets and Correlated States in Magic-angle Bilayer Graphene IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Superconductivity can occur under conditions approaching broken-symmetry parent states . In bilayer graphene, the twisting of one layer with respect to the other at ‘magic’ twist … |
XIAOBO LU et. al. |
| 2019 | 9 | The Clinical KRAS(G12C) Inhibitor AMG 510 Drives Anti-tumour Immunity IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: KRAS is the most frequently mutated oncogene in cancer and encodes a key signalling protein in tumours . The KRAS(G12C) mutant has a cysteine residue that has been exploited to … |
JUDE CANON et. al. |
| 2019 | 10 | Superconductivity at 250 K in Lanthanum Hydride Under High Pressures IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: With the discovery of superconductivity at 203 kelvin in H S, attention returned to conventional superconductors with properties that can be described by the … |
A P DROZDOV et. al. |
| 2018 | 1 | The UK Biobank Resource With Deep Phenotyping And Genomic Data IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged … |
CLARE BYCROFT et. al. |
| 2018 | 2 | Perovskite Light-emitting Diodes With External Quantum Efficiency Exceeding 20 Per Cent IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metal halide perovskite materials are an emerging class of solution-processable semiconductors with considerable potential for use in optoelectronic devices . For example, … |
KEBIN LIN et. al. |
| 2018 | 3 | RNA Velocity Of Single Cells IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and … |
GIOELE LA MANNO et. al. |
| 2018 | 4 | Machine Learning For Molecular And Materials Science IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Here we summarize recent progress in machine learning for the chemical sciences. We outline machine-learning techniques that are suitable for addressing research questions in this … |
Keith T Butler; Daniel W Davies; Hugh Cartwright; Olexandr Isayev; Aron Walsh; |
| 2018 | 5 | Exosomal PD-L1 Contributes To Immunosuppression And Is Associated With Anti-PD-1 Response IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T … |
GANG CHEN et. al. |
| 2018 | 6 | Options for Keeping The Food System Within Environmental Limits IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The food system is a major driver of climate change, changes in land use, depletion of freshwater resources, and pollution of aquatic and terrestrial ecosystems through excessive … |
MARCO SPRINGMANN et. al. |
| 2018 | 7 | Shared and Distinct Transcriptomic Cell Types Across Neocortical Areas IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The neocortex contains a multitude of cell types that are segregated into layers and functionally distinct areas. To investigate the diversity of cell types across the mouse … |
BOSILJKA TASIC et. al. |
| 2018 | 8 | Perovskite Light-emitting Diodes Based On Spontaneously Formed Submicrometre-scale Structures IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Light-emitting diodes (LEDs), which convert electricity to light, are widely used in modern society-for example, in lighting, flat-panel displays, medical devices and many other … |
YU CAO et. al. |
| 2018 | 9 | Addendum: The Cancer Cell Line Encyclopedia Enables Predictive Modelling of Anticancer Drug Sensitivity IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
JORDI BARRETINA et. al. |
| 2018 | 10 | Integrated Lithium Niobate Electro-optic Modulators Operating at CMOS-compatible Voltages IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Electro-optic modulators translate high-speed electronic signals into the optical domain and are critical components in modern telecommunication networks and microwave-photonic … |
CHENG WANG et. al. |
| 2017 | 1 | An Immunogenic Personal Neoantigen Vaccine For Patients With Melanoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Effective anti-tumour immunity in humans has been associated with the presence of T cells directed at cancer neoantigens, a class of HLA-bound peptides that arise from … |
PATRICK A OTT et. al. |
| 2017 | 2 | Personalized RNA Mutanome Vaccines Mobilize Poly-specific Therapeutic Immunity Against Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of … |
UGUR SAHIN et. al. |
| 2017 | 3 | Probing Many-body Dynamics On A 51-atom Quantum Simulator IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Controllable, coherent many-body systems can provide insights into the fundamental properties of quantum matter, enable the realization of new quantum phases and could ultimately … |
HANNES BERNIEN et. al. |
| 2017 | 4 | The Biology And Management Of Non-small Cell Lung Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been achieved over the past two decades, increasing our understanding of the disease biology and … |
Roy S Herbst; Daniel Morgensztern; Chris Boshoff; |
| 2017 | 5 | Architecture Of The Human Interactome Defines Protein Communities And Disease Networks IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks … |
EDWARD L HUTTLIN et. al. |
| 2017 | 6 | Phase Separation Drives Heterochromatin Domain Formation IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Constitutive heterochromatin is an important component of eukaryotic genomes that has essential roles in nuclear architecture, DNA repair and genome stability, and silencing of … |
AMY R STROM et. al. |
| 2017 | 7 | Exosomes Facilitate Therapeutic Targeting Of Oncogenic KRAS In Pancreatic Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, … |
SUSHRUT KAMERKAR et. al. |
| 2017 | 8 | Association Analysis Identifies 65 New Breast Cancer Risk Loci IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic … |
KYRIAKI MICHAILIDOU et. al. |
| 2017 | 9 | Satellite-to-ground Quantum Key Distribution IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Quantum key distribution (QKD) uses individual light quanta in quantum superposition states to guarantee unconditional communication security between distant parties. However, the … |
SHENG-KAI LIAO et. al. |
| 2017 | 10 | A Single-cell Survey Of The Small Intestinal Epithelium IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual … |
ADAM L HABER et. al. |
| 2016 | 1 | Genetic Effects On Gene Expression Across Human Tissues IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human … |
ALEXIS BATTLE et. al. |
| 2016 | 2 | A Multi-modal Parcellation Of Human Cerebral Cortex IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Understanding the amazingly complex human cerebral cortex requires a map (or parcellation) of its major subdivisions, known as cortical areas. Making an accurate areal map has … |
MATTHEW F GLASSER et. al. |
| 2016 | 3 | Programmable Editing Of A Target Base In Genomic DNA Without Double-stranded DNA Cleavage IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction. Although most genetic diseases arise from … |
Alexis C Komor; Yongjoo B Kim; Michael S Packer; John A Zuris; David R Liu; |
| 2016 | 4 | 1,500 Scientists Lift The Lid On Reproducibility IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Monya Baker; |
| 2016 | 5 | Global Warming And Recurrent Mass Bleaching Of Corals IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: During 2015-2016, record temperatures triggered a pan-tropical episode of coral bleaching, the third global-scale event since mass bleaching was first documented in the 1980s. … |
TERRY P HUGHES et. al. |
| 2016 | 6 | High-resolution Mapping Of Global Surface Water And Its Long-term Changes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The location and persistence of surface water (inland and coastal) is both affected by climate and human activity and affects climate, biological diversity and human wellbeing. … |
Jean-François Pekel; Andrew Cottam; Noel Gorelick; Alan S Belward; |
| 2016 | 7 | Metastable High-entropy Dual-phase Alloys Overcome The Strength-ductility Trade-off IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metals have been mankind’s most essential materials for thousands of years; however, their use is affected by ecological and economical concerns. Alloys with higher strength and … |
Zhiming Li; Konda Gokuldoss Pradeep; Yun Deng; Dierk Raabe; Cemal Cem Tasan; |
| 2016 | 8 | Hybrid Computing Using A Neural Network With Dynamic External Memory IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Artificial neural networks are remarkably adept at sensory processing, sequence learning and reinforcement learning, but are limited in their ability to represent variables and … |
ALEX GRAVES et. al. |
| 2016 | 9 | Genome-wide Association Study Identifies 74 Loci Associated With Educational Attainment IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across … |
AYSU OKBAY et. al. |
| 2016 | 10 | Decoding ALS: From Genes To Mechanism IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive and uniformly fatal neurodegenerative disease. A plethora of genetic factors have been identified that drive the degeneration … |
J Paul Taylor; Robert H Brown; Don W Cleveland; |
| 2015 | 1 | Mastering The Game Of Go With Deep Neural Networks And Tree Search IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The game of Go has long been viewed as the most challenging of classic games for artificial intelligence owing to its enormous search space and the difficulty of evaluating board … |
DAVID SILVER et. al. |
| 2015 | 2 | A Global Reference for Human Genetic Variation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from … |
ADAM AUTON et. al. |
| 2015 | 3 | Biomaterials IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Herb Brody; |
| 2015 | 4 | Tumour Exosome Integrins Determine Organotropic Metastasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, … |
AYUKO HOSHINO et. al. |
| 2015 | 5 | In Vivo Genome Editing Using Staphylococcus Aureus Cas9 IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its … |
F ANN RAN et. al. |
| 2015 | 6 | Fully Integrated Wearable Sensor Arrays For Multiplexed In Situ Perspiration Analysis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which … |
WEI GAO et. al. |
| 2015 | 7 | Cleavage Of GSDMD By Inflammatory Caspases Determines Pyroptotic Cell Death IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 … |
JIANJIN SHI et. al. |
| 2015 | 8 | The Effect Of Malaria Control On Plasmodium Falciparum In Africa Between 2000 And 2015 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this … |
S BHATT et. al. |
| 2015 | 9 | Analysis of Protein-coding Genetic Variation in 60,706 Humans IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and … |
MONKOL LEK et. al. |
| 2015 | 10 | Loophole-free Bell Inequality Violation Using Electron Spins Separated By 1.3 Kilometres IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: More than 50 years ago, John Bell proved that no theory of nature that obeys locality and realism can reproduce all the predictions of quantum theory: in any local-realist theory, … |
B HENSEN et. al. |
| 2014 | 1 | Human-level Control Through Deep Reinforcement Learning IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize … |
VOLODYMYR MNIH et. al. |
| 2014 | 2 | Integrative Analysis Of 111 Reference Human Epigenomes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To … |
ANSHUL KUNDAJE et. al. |
| 2014 | 3 | PD-1 Blockade Induces Responses By Inhibiting Adaptive Immune Resistance IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by … |
PAUL C TUMEH et. al. |
| 2014 | 4 | Predictive Correlates Of Response To The Anti-PD-L1 Antibody MPDL3280A In Cancer Patients IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression. These … |
ROY S HERBST et. al. |
| 2014 | 5 | The Contribution Of Outdoor Air Pollution Sources To Premature Mortality On A Global Scale IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Assessment of the global burden of disease is based on epidemiological cohort studies that connect premature mortality to a wide range of causes, including the long-term health … |
J Lelieveld; J S Evans; M Fnais; D Giannadaki; A Pozzer; |
| 2014 | 6 | High Secondary Aerosol Contribution To Particulate Pollution During Haze Events In China IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Rapid industrialization and urbanization in developing countries has led to an increase in air pollution, along a similar trajectory to that previously experienced by the … |
RU-JIN HUANG et. al. |
| 2014 | 7 | Design, Fabrication And Control Of Soft Robots IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Conventionally, engineers have employed rigid materials to fabricate precise, predictable robotic systems, which are easily modelled as rigid members connected at discrete joints. … |
Daniela Rus; Michael T Tolley; |
| 2014 | 8 | MPDL3280A (anti-PD-L1) Treatment Leads To Clinical Activity In Metastatic Bladder Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There have been no major advances for the treatment of metastatic urothelial bladder cancer (UBC) in the last 30 years. Chemotherapy is still the standard of care. Patient … |
THOMAS POWLES et. al. |
| 2014 | 9 | Synaptic, Transcriptional And Chromatin Genes Disrupted In Autism IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show … |
SILVIA DE RUBEIS et. al. |
| 2014 | 10 | Genome-scale Transcriptional Activation By An Engineered CRISPR-Cas9 Complex IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a … |
SILVANA KONERMANN et. al. |
| 2013 | 1 | Sequential Deposition As A Route To High-performance Perovskite-sensitized Solar Cells IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Following pioneering work, solution-processable organic-inorganic hybrid perovskites-such as CH3NH3PbX3 (X = Cl, Br, I)-have attracted attention as light-harvesting materials for … |
JULIAN BURSCHKA et. al. |
| 2013 | 2 | Signatures Of Mutational Processes In Human Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a … |
LUDMIL B ALEXANDROV et. al. |
| 2013 | 3 | Efficient Planar Heterojunction Perovskite Solar Cells By Vapour Deposition IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Many different photovoltaic technologies are being developed for large-scale solar energy conversion. The wafer-based first-generation photovoltaic devices have been followed by … |
Mingzhen Liu; Michael B Johnston; Henry J Snaith; |
| 2013 | 4 | The Global Distribution And Burden Of Dengue IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. For some patients, dengue is a life-threatening illness. There are currently no licensed … |
SAMIR BHATT et. al. |
| 2013 | 5 | Diet Rapidly And Reproducibly Alters The Human Gut Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly … |
LAWRENCE A DAVID et. al. |
| 2013 | 6 | Van Der Waals Heterostructures IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Research on graphene and other two-dimensional atomic crystals is intense and is likely to remain one of the leading topics in condensed matter physics and materials science for … |
A K Geim; I V Grigorieva; |
| 2013 | 7 | Circular RNAs Are A Large Class Of Animal RNAs With Regulatory Potency IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse … |
SEBASTIAN MEMCZAK et. al. |
| 2013 | 8 | Natural RNA Circles Function As Efficient MicroRNA Sponges IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that act by direct base pairing to target sites within untranslated regions of messenger RNAs. … |
THOMAS B HANSEN et. al. |
| 2013 | 9 | Mutational Landscape And Significance Across 12 Major Cancer Types IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical … |
CYRIAC KANDOTH et. al. |
| 2013 | 10 | Mutational Heterogeneity in Cancer and The Search for New Cancer-associated Genes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These … |
MICHAEL S LAWRENCE et. al. |
| 2012 | 1 | An Integrated Map of Genetic Variation from 1,092 Human Genomes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic … |
GONCALO R ABECASIS et. al. |
| 2012 | 2 | A Roadmap For Graphene IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent years have witnessed many breakthroughs in research on graphene (the first two-dimensional atomic crystal) as well as a significant advance in the mass production of this … |
K S NOVOSELOV et. al. |
| 2012 | 3 | Human Gut Microbiome Viewed Across Age And Geography IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize … |
TANYA YATSUNENKO et. al. |
| 2012 | 4 | Topological Domains In Mammalian Genomes Identified By Analysis Of Chromatin Interactions IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and … |
JESSE R DIXON et. al. |
| 2012 | 5 | The Cancer Cell Line Encyclopedia Enables Predictive Modeling of Anticancer Drug Sensitivity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by … |
JORDI BARRETINA et. al. |
| 2012 | 6 | Opportunities And Challenges For A Sustainable Energy Future IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Access to clean, affordable and reliable energy has been a cornerstone of the world’s increasing prosperity and economic growth since the beginning of the industrial revolution. … |
Steven Chu; Arun Majumdar; |
| 2012 | 7 | Biodiversity Loss And Its Impact On Humanity IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The most unique feature of Earth is the existence of life, and the most extraordinary feature of life is its diversity. Approximately 9 million types of plants, animals, protists … |
BRADLEY J CARDINALE et. al. |
| 2012 | 8 | The Genomic and Transcriptomic Architecture of 2,000 Breast Tumours Reveals Novel Subgroups IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We … |
CHRISTINA CURTIS et. al. |
| 2012 | 9 | A Metagenome-wide Association Study Of Gut Microbiota In Type 2 Diabetes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To … |
JUNJIE QIN et. al. |
| 2012 | 10 | Host-microbe Interactions Have Shaped The Genetic Architecture of Inflammatory Bowel Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in … |
LUKE JOSTINS et. al. |
| 2011 | 1 | Solutions For A Cultivated Planet IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished … |
JONATHAN A FOLEY et. al. |
| 2011 | 2 | Molecular Mechanisms And Clinical Applications Of Angiogenesis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the molecular mechanisms … |
Peter Carmeliet; Rakesh K Jain; |
| 2011 | 3 | Landscape Of Transcription In Human Cells IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these … |
SARAH DJEBALI et. al. |
| 2011 | 4 | Enterotypes Of The Human Gut Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about … |
MANIMOZHIYAN ARUMUGAM et. al. |
| 2011 | 5 | Persistence Of Soil Organic Matter As An Ecosystem Property IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Globally, soil organic matter (SOM) contains more than three times as much carbon as either the atmosphere or terrestrial vegetation. Yet it remains largely unknown why some SOM … |
MICHAEL W I SCHMIDT et. al. |
| 2011 | 6 | Gut Flora Metabolism of Phosphatidylcholine Promotes Cardiovascular Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death and morbidity … |
ZENENG WANG et. al. |
| 2011 | 7 | Progress And Challenges In Translating The Biology Of Atherosclerosis IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of productive life years worldwide. Research into the disease has led to many … |
Peter Libby; Paul M Ridker; Göran K Hansson; |
| 2011 | 8 | Cancer Immunotherapy Comes Of Age IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Activating the immune system for therapeutic benefit in cancer has long been a goal in immunology and oncology. After decades of disappointment, the tide has finally changed due … |
Ira Mellman; George Coukos; Glenn Dranoff; |
| 2011 | 9 | A Graphene-based Broadband Optical Modulator IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Integrated optical modulators with high modulation speed, small footprint and large optical bandwidth are poised to be the enabling devices for on-chip optical interconnects. … |
MING LIU et. al. |
| 2011 | 10 | Autophagy In Immunity And Inflammation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is … |
Beth Levine; Noboru Mizushima; Herbert W Virgin; |
| 2010 | 1 | A Human Gut Microbial Gene Catalogue Established By Metagenomic Sequencing IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic … |
JUNJIE QIN et. al. |
| 2010 | 2 | A Map Of Human Genome Variation From Population-scale Sequencing IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and … |
GONÇALO R ABECASIS et. al. |
| 2010 | 3 | The Next Generation Of Scenarios For Climate Change Research And Assessment IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Advances in the science and observation of climate change are providing a clearer understanding of the inherent variability of Earth’s climate system and its likely response to … |
RICHARD H MOSS et. al. |
| 2010 | 4 | Global Quantification Of Mammalian Gene Expression Control IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gene expression is a multistep process that involves the transcription, translation and turnover of messenger RNAs and proteins. Although it is one of the most fundamental … |
BJÖRN SCHWANHÄUSSER et. al. |
| 2010 | 5 | Long Noncoding RNA HOTAIR Reprograms Chromatin State to Promote Cancer Metastasis IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of … |
RAJNISH A. GUPTA et. al. |
| 2010 | 6 | Mammalian MicroRNAs Predominantly Act To Decrease Target MRNA Levels IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their … |
Huili Guo; Nicholas T Ingolia; Jonathan S Weissman; David P Bartel; |
| 2010 | 7 | Biological, Clinical And Population Relevance Of 95 Loci For Blood Lipids IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors … |
TANYA M TESLOVICH et. al. |
| 2010 | 8 | Genome Sequence of The Palaeopolyploid Soybean IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Soybean (Glycine max) is one of the most important crop plants for seed protein and oil content, and for its capacity to fix atmospheric nitrogen through symbioses with soil-borne … |
JEREMY SCHMUTZ et. al. |
| 2010 | 9 | Global Threats To Human Water Security And River Biodiversity IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Protecting the world’s freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to … |
C J VÖRÖSMARTY et. al. |
| 2010 | 10 | Cancer-associated IDH1 Mutations Produce 2-hydroxyglutarate IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
LENNY DANG et. al. |