Most Influential NATURE Papers
Nature is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, Nature features peer-reviewed research from a variety of academic disciplines, mainly in science, technology, and the natural sciences. Paper Digest Team analyze all papers published on NATURE in the past years, and presents the 10 most influential papers for each year. This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences, please visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards.
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TABLE 1: Most Influential NATURE Papers
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2020 | 1 | The Skin Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Michael Eisenstein; |
| 2020 | 2 | Human Neutralizing Antibodies Elicited By SARS-CoV-2 Infection IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that is in urgent need … |
BIN JU et. al. |
| 2020 | 3 | Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people and … |
DAVIDE F ROBBIANI et. al. |
| 2020 | 4 | Estimating The Effects of Non-pharmaceutical Interventions on COVID-19 in Europe IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Following the detection of the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its spread outside of China, Europe has experienced large epidemics … |
SETH FLAXMAN et. al. |
| 2020 | 5 | Factors Associated with COVID-19-related Death Using OpenSAFELY IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide . There is unprecedented urgency to understand who is most at risk of severe outcomes, and this … |
ELIZABETH J WILLIAMSON et. al. |
| 2020 | 6 | The Mutational Constraint Spectrum Quantified from Variation in 141,456 Humans IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the … |
KONRAD J KARCZEWSKI et. al. |
| 2020 | 7 | SARS-CoV-2-specific T Cell Immunity in Cases of COVID-19 and SARS, and Uninfected Controls IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections . Little is known about the presence in humans of … |
NINA LE BERT et. al. |
| 2020 | 8 | A Human Neutralizing Antibody Targets The Receptor-binding Site Of SARS-CoV-2 IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: An outbreak of coronavirus disease 2019 (COVID-19) , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) , has spread globally. Countermeasures are needed to … |
RUI SHI et. al. |
| 2020 | 9 | The Effect Of Large-scale Anti-contagion Policies On The COVID-19 Pandemic IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Governments around the world are responding to the coronavirus disease 2019 (COVID-19) pandemic , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with … |
SOLOMON HSIANG et. al. |
| 2020 | 10 | Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19 IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19) . However, the longitudinal immunological correlates of disease outcome remain … |
CAROLINA LUCAS et. al. |
| 2019 | 1 | Quantum Supremacy Using A Programmable Superconducting Processor IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The promise of quantum computers is that certain computational tasks might be executed exponentially faster on a quantum processor than on a classical processor . A fundamental … |
FRANK ARUTE et. al. |
| 2019 | 2 | The Structure Of DNA IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Georgina Ferry; |
| 2019 | 3 | Search-and-replace Genome Editing Without Double-strand Breaks Or Donor DNA IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Most genetic variants that contribute to disease are challenging to correct efficiently and without excess byproducts . Here we describe prime editing, a versatile and precise … |
ANDREW V ANZALONE et. al. |
| 2019 | 4 | Science And Society IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
ANNA ARMSTRONG et. al. |
| 2019 | 5 | Grandmaster Level In StarCraft II Using Multi-agent Reinforcement Learning IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Many real-world applications require artificial agents to compete and coordinate with other agents in complex environments. As a stepping stone to this goal, the domain of … |
ORIOL VINYALS et. al. |
| 2019 | 6 | Conserved Cell Types with Divergent Features in Human Versus Mouse Cortex IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus … |
REBECCA D HODGE et. al. |
| 2019 | 7 | Multi-omics of The Gut Microbial Ecosystem in Inflammatory Bowel Diseases IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, affect several million individuals worldwide. Crohn’s disease and ulcerative colitis are complex … |
JASON LLOYD-PRICE et. al. |
| 2019 | 8 | Superconductors, Orbital Magnets And Correlated States In Magic-angle Bilayer Graphene IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Superconductivity can occur under conditions approaching broken-symmetry parent states . In bilayer graphene, the twisting of one layer with respect to the other at ‘magic’ twist … |
XIAOBO LU et. al. |
| 2019 | 9 | The Clinical KRAS(G12C) Inhibitor AMG 510 Drives Anti-tumour Immunity IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: KRAS is the most frequently mutated oncogene in cancer and encodes a key signalling protein in tumours . The KRAS(G12C) mutant has a cysteine residue that has been exploited to … |
JUDE CANON et. al. |
| 2019 | 10 | A Clinically Applicable Approach to Continuous Prediction of Future Acute Kidney Injury IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The early prediction of deterioration could have an important role in supporting healthcare professionals, as an estimated 11% of deaths in hospital follow a failure to promptly … |
NENAD TOMAŠEV et. al. |
| 2018 | 1 | The UK Biobank Resource With Deep Phenotyping And Genomic Data IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged … |
CLARE BYCROFT et. al. |
| 2018 | 2 | Exosomal PD-L1 Contributes To Immunosuppression And Is Associated With Anti-PD-1 Response IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T … |
GANG CHEN et. al. |
| 2018 | 3 | Perovskite Light-emitting Diodes With External Quantum Efficiency Exceeding 20 Per Cent IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metal halide perovskite materials are an emerging class of solution-processable semiconductors with considerable potential for use in optoelectronic devices . For example, … |
KEBIN LIN et. al. |
| 2018 | 4 | RNA Velocity Of Single Cells IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and … |
GIOELE LA MANNO et. al. |
| 2018 | 5 | Machine Learning For Molecular And Materials Science IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Here we summarize recent progress in machine learning for the chemical sciences. We outline machine-learning techniques that are suitable for addressing research questions in this … |
Keith T Butler; Daniel W Davies; Hugh Cartwright; Olexandr Isayev; Aron Walsh; |
| 2018 | 6 | Single-cell Transcriptomics Of 20 Mouse Organs Creates A Tabula Muris IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Here we present a compendium of single-cell transcriptomic data from the model organism Mus musculus that comprises more than 100,000 cells from 20 organs and tissues. These data … |
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| 2018 | 7 | Equivalent-accuracy Accelerated Neural-network Training Using Analogue Memory IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Neural-network training can be slow and energy intensive, owing to the need to transfer the weight data for the network between conventional digital memory chips and processor … |
STEFANO AMBROGIO et. al. |
| 2018 | 8 | Integrated Lithium Niobate Electro-optic Modulators Operating At CMOS-compatible Voltages IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Electro-optic modulators translate high-speed electronic signals into the optical domain and are critical components in modern telecommunication networks and microwave-photonic … |
CHENG WANG et. al. |
| 2018 | 9 | Options for Keeping The Food System Within Environmental Limits IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The food system is a major driver of climate change, changes in land use, depletion of freshwater resources, and pollution of aquatic and terrestrial ecosystems through excessive … |
MARCO SPRINGMANN et. al. |
| 2018 | 10 | Perovskite Light-emitting Diodes Based On Spontaneously Formed Submicrometre-scale Structures IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Light-emitting diodes (LEDs), which convert electricity to light, are widely used in modern society-for example, in lighting, flat-panel displays, medical devices and many other … |
YU CAO et. al. |
| 2017 | 1 | Blood IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Herb Brody; |
| 2017 | 2 | An Immunogenic Personal Neoantigen Vaccine For Patients With Melanoma IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Effective anti-tumour immunity in humans has been associated with the presence of T cells directed at cancer neoantigens, a class of HLA-bound peptides that arise from … |
PATRICK A OTT et. al. |
| 2017 | 3 | Personalized RNA Mutanome Vaccines Mobilize Poly-specific Therapeutic Immunity Against Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of … |
UGUR SAHIN et. al. |
| 2017 | 4 | Architecture Of The Human Interactome Defines Protein Communities And Disease Networks IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks … |
EDWARD L HUTTLIN et. al. |
| 2017 | 5 | Exosomes Facilitate Therapeutic Targeting Of Oncogenic KRAS In Pancreatic Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, … |
SUSHRUT KAMERKAR et. al. |
| 2017 | 6 | Probing Many-body Dynamics On A 51-atom Quantum Simulator IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Controllable, coherent many-body systems can provide insights into the fundamental properties of quantum matter, enable the realization of new quantum phases and could ultimately … |
HANNES BERNIEN et. al. |
| 2017 | 7 | Phase Separation Drives Heterochromatin Domain Formation IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Constitutive heterochromatin is an important component of eukaryotic genomes that has essential roles in nuclear architecture, DNA repair and genome stability, and silencing of … |
AMY R STROM et. al. |
| 2017 | 8 | The Biology And Management Of Non-small Cell Lung Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been achieved over the past two decades, increasing our understanding of the disease biology and … |
Roy S Herbst; Daniel Morgensztern; Chris Boshoff; |
| 2017 | 9 | Association Analysis Identifies 65 New Breast Cancer Risk Loci IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic … |
KYRIAKI MICHAILIDOU et. al. |
| 2017 | 10 | Quantitative Microbiome Profiling Links Gut Community Variation To Microbial Load IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Current sequencing-based analyses of faecal microbiota quantify microbial taxa and metabolic pathways as fractions of the sample sequence library generated by each analysis. … |
DORIS VANDEPUTTE et. al. |
| 2016 | 1 | Programmable Editing Of A Target Base In Genomic DNA Without Double-stranded DNA Cleavage IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction. Although most genetic diseases arise from … |
Alexis C Komor; Yongjoo B Kim; Michael S Packer; John A Zuris; David R Liu; |
| 2016 | 2 | Genetic Effects On Gene Expression Across Human Tissues IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human … |
et. al. |
| 2016 | 3 | Metastable High-entropy Dual-phase Alloys Overcome The Strength-ductility Trade-off IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metals have been mankind’s most essential materials for thousands of years; however, their use is affected by ecological and economical concerns. Alloys with higher strength and … |
Zhiming Li; Konda Gokuldoss Pradeep; Yun Deng; Dierk Raabe; Cemal Cem Tasan; |
| 2016 | 4 | A Multi-modal Parcellation Of Human Cerebral Cortex IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Understanding the amazingly complex human cerebral cortex requires a map (or parcellation) of its major subdivisions, known as cortical areas. Making an accurate areal map has … |
MATTHEW F GLASSER et. al. |
| 2016 | 5 | 1,500 Scientists Lift The Lid On Reproducibility IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Monya Baker; |
| 2016 | 6 | Global Warming And Recurrent Mass Bleaching Of Corals IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: During 2015-2016, record temperatures triggered a pan-tropical episode of coral bleaching, the third global-scale event since mass bleaching was first documented in the 1980s. … |
TERRY P HUGHES et. al. |
| 2016 | 7 | High-resolution Mapping Of Global Surface Water And Its Long-term Changes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The location and persistence of surface water (inland and coastal) is both affected by climate and human activity and affects climate, biological diversity and human wellbeing. … |
Jean-François Pekel; Andrew Cottam; Noel Gorelick; Alan S Belward; |
| 2016 | 8 | Hybrid Computing Using A Neural Network With Dynamic External Memory IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Artificial neural networks are remarkably adept at sensory processing, sequence learning and reinforcement learning, but are limited in their ability to represent variables and … |
ALEX GRAVES et. al. |
| 2016 | 9 | The Brazilian Zika Virus Strain Causes Birth Defects In Experimental Models IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus … |
FERNANDA R CUGOLA et. al. |
| 2016 | 10 | Genome-wide Association Study Identifies 74 Loci Associated With Educational Attainment IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across … |
AYSU OKBAY et. al. |
| 2015 | 1 | In Vivo Genome Editing Using Staphylococcus Aureus Cas9 IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its … |
F ANN RAN et. al. |
| 2015 | 2 | Mastering The Game Of Go With Deep Neural Networks And Tree Search IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The game of Go has long been viewed as the most challenging of classic games for artificial intelligence owing to its enormous search space and the difficulty of evaluating board … |
DAVID SILVER et. al. |
| 2015 | 3 | Tumour Exosome Integrins Determine Organotropic Metastasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, … |
AYUKO HOSHINO et. al. |
| 2015 | 4 | Fully Integrated Wearable Sensor Arrays For Multiplexed In Situ Perspiration Analysis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which … |
WEI GAO et. al. |
| 2015 | 5 | An Ultrafast Rechargeable Aluminium-ion Battery IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The development of new rechargeable battery systems could fuel various energy applications, from personal electronics to grid storage. Rechargeable aluminium-based batteries offer … |
MENG-CHANG LIN et. al. |
| 2015 | 6 | A Global Reference for Human Genetic Variation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from … |
ADAM AUTON et. al. |
| 2015 | 7 | Loophole-free Bell Inequality Violation Using Electron Spins Separated By 1.3 Kilometres IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: More than 50 years ago, John Bell proved that no theory of nature that obeys locality and realism can reproduce all the predictions of quantum theory: in any local-realist theory, … |
B HENSEN et. al. |
| 2015 | 8 | Glypican-1 Identifies Cancer Exosomes And Detects Early Pancreatic Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic acids. They are secreted by all cells and circulate in the blood. Specific detection … |
SONIA A MELO et. al. |
| 2015 | 9 | Epithelial-to-mesenchymal Transition Is Not Required For Lung Metastasis But Contributes To Chemoresistance IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and reversible EMT … |
KARI R FISCHER et. al. |
| 2015 | 10 | Type-II Weyl Semimetals IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Fermions–elementary particles such as electrons–are classified as Dirac, Majorana or Weyl. Majorana and Weyl fermions had not been observed experimentally until the recent … |
ALEXEY A SOLUYANOV et. al. |
| 2014 | 1 | Human-level Control Through Deep Reinforcement Learning IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize … |
VOLODYMYR MNIH et. al. |
| 2014 | 2 | Genome-scale Transcriptional Activation By An Engineered CRISPR-Cas9 Complex IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a … |
SILVANA KONERMANN et. al. |
| 2014 | 3 | Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Herb Brody; |
| 2014 | 4 | PD-1 Blockade Induces Responses By Inhibiting Adaptive Immune Resistance IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by … |
PAUL C TUMEH et. al. |
| 2014 | 5 | Lung Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Herb Brody; |
| 2014 | 6 | Predictive Correlates Of Response To The Anti-PD-L1 Antibody MPDL3280A In Cancer Patients IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression. These … |
ROY S HERBST et. al. |
| 2014 | 7 | MPDL3280A (anti-PD-L1) Treatment Leads To Clinical Activity In Metastatic Bladder Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There have been no major advances for the treatment of metastatic urothelial bladder cancer (UBC) in the last 30 years. Chemotherapy is still the standard of care. Patient … |
THOMAS POWLES et. al. |
| 2014 | 8 | Obesity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Tony Scully; |
| 2014 | 9 | Solution-processed, High-performance Light-emitting Diodes Based On Quantum Dots IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Solution-processed optoelectronic and electronic devices are attractive owing to the potential for low-cost fabrication of large-area devices and the compatibility with … |
XINGLIANG DAI et. al. |
| 2014 | 10 | Design, Fabrication And Control Of Soft Robots IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Conventionally, engineers have employed rigid materials to fabricate precise, predictable robotic systems, which are easily modelled as rigid members connected at discrete joints. … |
Daniela Rus; Michael T Tolley; |
| 2013 | 1 | Treg Induction By A Rationally Selected Mixture Of Clostridia Strains From The Human Microbiota IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous probiotic microorganisms have been identified, … |
KOJI ATARASHI et. al. |
| 2013 | 2 | Structural And Molecular Interrogation Of Intact Biological Systems IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Obtaining high-resolution information from a complex system, while maintaining the global perspective needed to understand system function, represents a key challenge in biology. … |
KWANGHUN CHUNG et. al. |
| 2013 | 3 | Efficient Planar Heterojunction Perovskite Solar Cells By Vapour Deposition IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Many different photovoltaic technologies are being developed for large-scale solar energy conversion. The wafer-based first-generation photovoltaic devices have been followed by … |
Mingzhen Liu; Michael B Johnston; Henry J Snaith; |
| 2013 | 4 | Circular RNAs Are A Large Class Of Animal RNAs With Regulatory Potency IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse … |
SEBASTIAN MEMCZAK et. al. |
| 2013 | 5 | Natural RNA Circles Function As Efficient MicroRNA Sponges IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that act by direct base pairing to target sites within untranslated regions of messenger RNAs. … |
THOMAS B HANSEN et. al. |
| 2013 | 6 | Non-invasive Analysis of Acquired Resistance to Cancer Therapy By Sequencing of Plasma DNA IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancers acquire resistance to systemic treatment as a result of clonal evolution and selection. Repeat biopsies to study genomic evolution as a result of therapy are difficult, … |
MUHAMMED MURTAZA et. al. |
| 2013 | 7 | Sequential Deposition As A Route To High-performance Perovskite-sensitized Solar Cells IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Following pioneering work, solution-processable organic-inorganic hybrid perovskites-such as CH3NH3PbX3 (X = Cl, Br, I)-have attracted attention as light-harvesting materials for … |
JULIAN BURSCHKA et. al. |
| 2013 | 8 | Signatures Of Mutational Processes In Human Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a … |
LUDMIL B ALEXANDROV et. al. |
| 2013 | 9 | Diet Rapidly And Reproducibly Alters The Human Gut Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly … |
LAWRENCE A DAVID et. al. |
| 2013 | 10 | Mutational Landscape And Significance Across 12 Major Cancer Types IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical … |
CYRIAC KANDOTH et. al. |
| 2012 | 1 | RNA-guided Genetic Silencing Systems In Bacteria And Archaea IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and … |
Blake Wiedenheft; Samuel H Sternberg; Jennifer A Doudna; |
| 2012 | 2 | Structure, Function And Diversity Of The Healthy Human Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this … |
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| 2012 | 3 | Highly Efficient Organic Light-emitting Diodes From Delayed Fluorescence IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The inherent flexibility afforded by molecular design has accelerated the development of a wide variety of organic semiconductors over the past two decades. In particular, great … |
Hiroki Uoyama; Kenichi Goushi; Katsuyuki Shizu; Hiroko Nomura; Chihaya Adachi; |
| 2012 | 4 | EZH2 Inhibition As A Therapeutic Strategy For Lymphoma With EZH2-activating Mutations IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In eukaryotes, post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the polycomb … |
MICHAEL T MCCABE et. al. |
| 2012 | 5 | Diversity, Stability And Resilience Of The Human Gut Microbiota IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective … |
Catherine A Lozupone; Jesse I Stombaugh; Jeffrey I Gordon; Janet K Jansson; Rob Knight; |
| 2012 | 6 | Highly Stretchable And Tough Hydrogels IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hydrogels are used as scaffolds for tissue engineering, vehicles for drug delivery, actuators for optics and fluidics, and model extracellular matrices for biological studies. The … |
JEONG-YUN SUN et. al. |
| 2012 | 7 | An Integrated Map of Genetic Variation from 1,092 Human Genomes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic … |
GONCALO R ABECASIS et. al. |
| 2012 | 8 | Opportunities And Challenges For A Sustainable Energy Future IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Access to clean, affordable and reliable energy has been a cornerstone of the world’s increasing prosperity and economic growth since the beginning of the industrial revolution. … |
Steven Chu; Arun Majumdar; |
| 2012 | 9 | The Genomic and Transcriptomic Architecture of 2,000 Breast Tumours Reveals Novel Subgroups IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We … |
CHRISTINA CURTIS et. al. |
| 2012 | 10 | A Metagenome-wide Association Study Of Gut Microbiota In Type 2 Diabetes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To … |
JUNJIE QIN et. al. |
| 2011 | 1 | Cancer Immunotherapy Comes Of Age IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Activating the immune system for therapeutic benefit in cancer has long been a goal in immunology and oncology. After decades of disappointment, the tide has finally changed due … |
Ira Mellman; George Coukos; Glenn Dranoff; |
| 2011 | 2 | An Integrated Semiconductor Device Enabling Non-optical Genome Sequencing IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The seminal importance of DNA sequencing to the life sciences, biotechnology and medicine has driven the search for more scalable and lower-cost solutions. Here we describe a DNA … |
JONATHAN M ROTHBERG et. al. |
| 2011 | 3 | RNAi Screen Identifies Brd4 As A Therapeutic Target In Acute Myeloid Leukaemia IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and … |
JOHANNES ZUBER et. al. |
| 2011 | 4 | Neocortical Excitation/inhibition Balance In Information Processing And Social Dysfunction IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have been hypothesized to arise from elevations in the cellular balance of excitation and … |
OFER YIZHAR et. al. |
| 2011 | 5 | Perpendicular Switching Of A Single Ferromagnetic Layer Induced By In-plane Current Injection IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Modern computing technology is based on writing, storing and retrieving information encoded as magnetic bits. Although the giant magnetoresistance effect has improved the … |
IOAN MIHAI MIRON et. al. |
| 2011 | 6 | Broad Neutralization Coverage Of HIV By Multiple Highly Potent Antibodies IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the … |
LAURA M WALKER et. al. |
| 2011 | 7 | Enterotypes Of The Human Gut Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about … |
MANIMOZHIYAN ARUMUGAM et. al. |
| 2011 | 8 | Bioinspired Self-repairing Slippery Surfaces With Pressure-stable Omniphobicity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Creating a robust synthetic surface that repels various liquids would have broad technological implications for areas ranging from biomedical devices and fuel transport to … |
TAK-SING WONG et. al. |
| 2011 | 9 | An Integrated Encyclopedia of DNA Elements in The Human Genome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) … |
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| 2011 | 10 | A Graphene-based Broadband Optical Modulator IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Integrated optical modulators with high modulation speed, small footprint and large optical bandwidth are poised to be the enabling devices for on-chip optical interconnects. … |
MING LIU et. al. |
| 2010 | 1 | Selective Inhibition Of BET Bromodomains IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic … |
PANAGIS FILIPPAKOPOULOS et. al. |
| 2010 | 2 | Direct Conversion Of Fibroblasts To Functional Neurons By Defined Factors IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts … |
THOMAS VIERBUCHEN et. al. |
| 2010 | 3 | CRISPR RNA Maturation By Trans-encoded Small RNA And Host Factor RNase III IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: CRISPR/Cas systems constitute a widespread class of immunity systems that protect bacteria and archaea against phages and plasmids, and commonly use repeat/spacer-derived short … |
ELITZA DELTCHEVA et. al. |
| 2010 | 4 | The CRISPR/Cas Bacterial Immune System Cleaves Bacteriophage And Plasmid DNA IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bacteria and Archaea have developed several defence strategies against foreign nucleic acids such as viral genomes and plasmids. Among them, clustered regularly interspaced short … |
JOSIANE E GARNEAU et. al. |
| 2010 | 5 | Cancer-associated IDH1 Mutations Produce 2-hydroxyglutarate IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
LENNY DANG et. al. |
| 2010 | 6 | Evidence Of RNAi In Humans From Systemically Administered SiRNA Via Targeted Nanoparticles IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Therapeutics that are designed to engage RNA interference (RNAi) pathways have the potential to provide new, major ways of imparting therapy to patients. Long, double-stranded … |
MARK E DAVIS et. al. |
| 2010 | 7 | Functional Impact Of Global Rare Copy Number Variation In Autism Spectrum Disorders IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and … |
DALILA PINTO et. al. |
| 2010 | 8 | Suppression Of Inflammation By A Synthetic Histone Mimic IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune defence, is frequently … |
EDWIGE NICODEME et. al. |
| 2010 | 9 | The Landscape of Somatic Copy-number Alteration Across Human Cancers IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present … |
RAMEEN BEROUKHIM et. al. |
| 2010 | 10 | Simultaneous Phase and Size Control of Upconversion Nanocrystals Through Lanthanide Doping IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Doping is a widely applied technological process in materials science that involves incorporating atoms or ions of appropriate elements into host lattices to yield hybrid … |
FENG WANG et. al. |