Most Influential CELL Papers
Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and computational biology. Paper Digest Team analyze all papers published on CELL in the past years, and presents the 10 most influential papers for each year. This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences, please visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards.
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TABLE 1: Most Influential CELL Papers
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2020 | 1 | Structure, Function, and Antigenicity of The SARS-CoV-2 Spike Glycoprotein IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
ALEXANDRA C WALLS et. al. |
| 2020 | 2 | Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of The COVID-19 Virus IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed … |
BETTE KORBER et. al. |
| 2020 | 3 | Robust T Cell Immunity in Convalescent Individuals with Asymptomatic Or Mild COVID-19 IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic … |
TAKUYA SEKINE et. al. |
| 2020 | 4 | A SARS-CoV-2 Infection Model in Mice Demonstrates Protection By Neutralizing Antibodies IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of potential therapies and … |
AHMED O HASSAN et. al. |
| 2020 | 5 | The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The spike protein of SARS-CoV-2 has been undergoing mutations and is highly glycosylated. It is critically important to investigate the biological significance of these mutations. … |
QIANQIAN LI et. al. |
| 2020 | 6 | The Global Phosphorylation Landscape of SARS-CoV-2 Infection IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of … |
MEHDI BOUHADDOU et. al. |
| 2020 | 7 | Making Sense of Mutation: What D614G Means for The COVID-19 Pandemic Remains Unclear IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data … |
Nathan D Grubaugh; William P Hanage; Angela L Rasmussen; |
| 2020 | 8 | Severe COVID-19 Is Marked By A Dysregulated Myeloid Cell Compartment IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The … |
JONAS SCHULTE-SCHREPPING et. al. |
| 2020 | 9 | Generation of A Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and … |
JING SUN et. al. |
| 2020 | 10 | Structural and Functional Analysis of The D614G SARS-CoV-2 Spike Protein Variant IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Here we show that D614G was more infectious … |
LEONID YURKOVETSKIY et. al. |
| 2019 | 1 | Comprehensive Integration Of Single-Cell Data IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing of clusters. As new … |
TIM STUART et. al. |
| 2019 | 2 | An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Here, … |
CYRIL NEFTEL et. al. |
| 2019 | 3 | Cellular Senescence: Defining A Path Forward IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting … |
VASSILIS GORGOULIS et. al. |
| 2019 | 4 | Single-Cell Multi-omic Integration Compares And Contrasts Features Of Brain Cell Identity IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Defining cell types requires integrating diverse single-cell measurements from multiple experiments and biological contexts. To flexibly model single-cell datasets, we developed … |
JOSHUA D WELCH et. al. |
| 2019 | 5 | Alzheimer Disease: An Update On Pathobiology And Treatment Strategies IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular … |
Justin M Long; David M Holtzman; |
| 2019 | 6 | Organization of Chromatin By Intrinsic and Regulated Phase Separation IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Eukaryotic chromatin is highly condensed but dynamically accessible to regulation and organized into subdomains. We demonstrate that reconstituted chromatin undergoes histone … |
BRYAN A GIBSON et. al. |
| 2019 | 7 | A Cellular Taxonomy Of The Bone Marrow Stroma In Homeostasis And Leukemia IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Stroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma have … |
NINIB BARYAWNO et. al. |
| 2019 | 8 | The Role Of Non-coding RNAs In Oncology IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding … |
Frank J Slack; Arul M Chinnaiyan; |
| 2019 | 9 | The Translational Landscape of The Human Heart IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human … |
SEBASTIAAN VAN HEESCH et. al. |
| 2019 | 10 | Stromal Microenvironment Shapes The Intratumoral Architecture of Pancreatic Cancer IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been well defined. … |
MATTEO LIGORIO et. al. |
| 2018 | 1 | The Human Transcription Factors IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
SAMUEL A LAMBERT et. al. |
| 2018 | 2 | Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
ANTONI RIBAS et. al. |
| 2018 | 3 | Innate Lymphoid Cells: 10 Years On IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells … |
ERIC VIVIER et. al. |
| 2018 | 4 | Recovering Gene Interactions from Single-Cell Data Using Data Diffusion IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Single-cell RNA sequencing technologies suffer from many sources of technical noise, including under-sampling of mRNA molecules, often termed dropout, which can severely obscure … |
DAVID VAN DIJK et. al. |
| 2018 | 5 | Single-Cell Map of Diverse Immune Phenotypes in The Breast Tumor Microenvironment IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We profiled 45,000 … |
ELHAM AZIZI et. al. |
| 2018 | 6 | A Molecular Grammar Governing The Driving Forces for Phase Separation of Prion-like RNA Binding Proteins IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Proteins such as FUS phase separate to form liquid-like condensates that can harden into less dynamic structures. However, how these properties emerge from the collective … |
JIE WANG et. al. |
| 2018 | 7 | Reassessment Of Exosome Composition IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular matter have led to debate about contents and functional properties of exosomes. Here, … |
DENNIS K JEPPESEN et. al. |
| 2018 | 8 | Biological Functions Of Autophagy Genes: A Disease Perspective IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved … |
Beth Levine; Guido Kroemer; |
| 2018 | 9 | Considerations And Challenges In Studying Liquid-Liquid Phase Separation And Biomolecular Condensates IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells. This realization has motivated major efforts to … |
Simon Alberti; Amy Gladfelter; Tanja Mittag; |
| 2018 | 10 | Universal Patterns of Selection in Cancer and Somatic Tissues IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
IÑIGO MARTINCORENA et. al. |
| 2017 | 1 | Identifying Medical Diagnoses And Treatable Diseases By Image-Based Deep Learning IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The implementation of clinical-decision support algorithms for medical imaging faces challenges with reliability and interpretability. Here, we establish a diagnostic tool based … |
DANIEL S KERMANY et. al. |
| 2017 | 2 | Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, And Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that … |
BRENT R STOCKWELL et. al. |
| 2017 | 3 | Comprehensive Molecular Characterization Of Muscle-Invasive Bladder Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and … |
A GORDON ROBERTSON et. al. |
| 2017 | 4 | Functional Classification and Experimental Dissection of Long Noncoding RNAs IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over the last decade, it has been increasingly demonstrated that the genomes of many species are pervasively transcribed, resulting in the production of numerous long noncoding … |
Florian Kopp; Joshua T Mendell; |
| 2017 | 5 | Cohesin Loss Eliminates All Loop Domains IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The human genome folds to create thousands of intervals, called contact domains, that exhibit enhanced contact frequency within themselves. Loop domains form because of … |
SUHAS S P RAO et. al. |
| 2017 | 6 | Comprehensive Characterization of Cancer Driver Genes and Mutations IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and … |
MATTHEW H BAILEY et. al. |
| 2017 | 7 | Oncogenic Signaling Pathways in The Cancer Genome Atlas IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and … |
FRANCISCO SANCHEZ-VEGA et. al. |
| 2017 | 8 | A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures. Here, we … |
ARAVIND SUBRAMANIAN et. al. |
| 2017 | 9 | The PI3K Pathway In Human Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K … |
DAVID A FRUMAN et. al. |
| 2017 | 10 | An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors … |
JIANFANG LIU et. al. |
| 2016 | 1 | Primary, Adaptive, And Acquired Resistance To Cancer Immunotherapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these … |
Padmanee Sharma; Siwen Hu-Lieskovan; Jennifer A Wargo; Antoni Ribas; |
| 2016 | 2 | MTOR Signaling In Growth, Metabolism, And Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research … |
Robert A Saxton; David M Sabatini; |
| 2016 | 3 | Abiotic Stress Signaling And Responses In Plants IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: As sessile organisms, plants must cope with abiotic stress such as soil salinity, drought, and extreme temperatures. Core stress-signaling pathways involve protein kinases related … |
Jian-Kang Zhu; |
| 2016 | 4 | Systemic Spread Of Sequence-Specific Transgene RNA Degradation In Plants Is Initiated By Localized Introduction Of Ectopic Promoterless DNA IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Olivier Voinnet; Philippe Vain; Susan Angell; David C Baulcombe; |
| 2016 | 5 | Clonal Heterogeneity And Tumor Evolution: Past, Present, And The Future IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have revealed intra-tumor heterogeneity … |
Nicholas McGranahan; Charles Swanton; |
| 2016 | 6 | A Viral Movement Protein Prevents Spread Of The Gene Silencing Signal In Nicotiana Benthamiana IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Olivier Voinnet; Carsten Lederer; David C Baulcombe; |
| 2016 | 7 | CRISPR-Based Technologies For The Manipulation Of Eukaryotic Genomes IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. … |
Alexis C Komor; Ahmed H Badran; David R Liu; |
| 2016 | 8 | Zika Virus Infection During Pregnancy In Mice Causes Placental Damage And Fetal Demise IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental and … |
JONATHAN J MINER et. al. |
| 2016 | 9 | Perturb-Seq: Dissecting Molecular Circuits With Scalable Single-Cell RNA Profiling Of Pooled Genetic Screens IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genetic screens help infer gene function in mammalian cells, but it has remained difficult to assay complex phenotypes-such as transcriptional profiles-at scale. Here, we develop … |
ATRAY DIXIT et. al. |
| 2016 | 10 | Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Activated effector T (TE) cells augment anabolic pathways of metabolism, such as aerobic glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid oxidation … |
MICHAEL D BUCK et. al. |
| 2015 | 1 | Cpf1 Is A Single RNA-guided Endonuclease Of A Class 2 CRISPR-Cas System IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize … |
BERND ZETSCHE et. al. |
| 2015 | 2 | Metabolic Competition In The Tumor Microenvironment Is A Driver Of Cancer Progression IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma … |
CHIH-HAO CHANG et. al. |
| 2015 | 3 | The Molecular Taxonomy Of Primary Prostate Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer … |
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| 2015 | 4 | Communication By Extracellular Vesicles: Where We Are And Where We Need To Go IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In multicellular organisms, distant cells can exchange information by sending out signals composed of single molecules or, as increasingly exemplified in the literature, via … |
Mercedes Tkach; Clotilde Théry; |
| 2015 | 5 | Disruptions Of Topological Chromatin Domains Cause Pathogenic Rewiring Of Gene-enhancer Interactions IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demonstrate that disruption of TADs can rewire long-range regulatory architecture … |
DARÍO G LUPIÁÑEZ et. al. |
| 2015 | 6 | Personalized Nutrition By Prediction Of Glycemic Responses IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling … |
DAVID ZEEVI et. al. |
| 2015 | 7 | Phase Separation By Low Complexity Domains Promotes Stress Granule Assembly And Drives Pathological Fibrillization IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Stress granules are membrane-less organelles composed of RNA-binding proteins (RBPs) and RNA. Functional impairment of stress granules has been implicated in amyotrophic lateral … |
AMANDINE MOLLIEX et. al. |
| 2015 | 8 | On The Dependency Of Cellular Protein Levels On MRNA Abundance IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The question of how genomic information is expressed to determine phenotypes is of central importance for basic and translational life science research and has been studied by … |
Yansheng Liu; Andreas Beyer; Ruedi Aebersold; |
| 2015 | 9 | Molecular Profiling Reveals Biologically Discrete Subsets And Pathways Of Progression In Diffuse Glioma IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the … |
MICHELE CECCARELLI et. al. |
| 2015 | 10 | Hippo Pathway In Organ Size Control, Tissue Homeostasis, And Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ … |
Fa-Xing Yu; Bin Zhao; Kun-Liang Guan; |
| 2014 | 1 | Highly Parallel Genome-wide Expression Profiling Of Individual Cells Using Nanoliter Droplets IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cells, the basic units of biological structure and function, vary broadly in type and state. Single-cell genomics can characterize cell identity and function, but limitations of … |
EVAN Z MACOSKO et. al. |
| 2014 | 2 | Development and Applications of CRISPR-Cas9 for Genome Engineering IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of mammalian genome … |
Patrick D Hsu; Eric S Lander; Feng Zhang; |
| 2014 | 3 | Droplet Barcoding For Single-cell Transcriptomics Applied To Embryonic Stem Cells IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: It has long been the dream of biologists to map gene expression at the single-cell level. With such data one might track heterogeneous cell sub-populations, and infer regulatory … |
ALLON M KLEIN et. al. |
| 2014 | 4 | Genome-Scale CRISPR-Mediated Control Of Gene Repression And Activation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: While the catalog of mammalian transcripts and their expression levels in different cell types and disease states is rapidly expanding, our understanding of transcript function … |
LUKE A GILBERT et. al. |
| 2014 | 5 | Genomic Classification Of Cutaneous Melanoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. … |
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| 2014 | 6 | A 3D Map Of The Human Genome At Kilobase Resolution Reveals Principles Of Chromatin Looping IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 … |
SUHAS S P RAO et. al. |
| 2014 | 7 | Human Genetics Shape The Gut Microbiome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect … |
JULIA K GOODRICH et. al. |
| 2014 | 8 | Molecular And Genetic Properties Of Tumors Associated With Local Immune Cytolytic Activity IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: How the genomic landscape of a tumor shapes and is shaped by anti-tumor immunity has not been systematically explored. Using large-scale genomic data sets of solid tissue tumor … |
Michael S Rooney; Sachet A Shukla; Catherine J Wu; Gad Getz; Nir Hacohen; |
| 2014 | 9 | CRISPR-Cas9 Knockin Mice For Genome Editing And Cancer Modeling IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a … |
RANDALL J PLATT et. al. |
| 2014 | 10 | Integrated Genomic Characterization Of Papillary Thyroid Carcinoma IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic … |
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| 2013 | 1 | One-step Generation Of Mice Carrying Mutations In Multiple Genes By CRISPR/Cas-mediated Genome Engineering IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mice carrying mutations in multiple genes are traditionally generated by sequential recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a single … |
HAOYI WANG et. al. |
| 2013 | 2 | CRISPR-mediated Modular RNA-guided Regulation Of Transcription In Eukaryotes IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or repression. The CRISPR-associated catalytically … |
LUKE A GILBERT et. al. |
| 2013 | 3 | Double Nicking By RNA-guided CRISPR Cas9 For Enhanced Genome Editing Specificity IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is targeted to … |
F ANN RAN et. al. |
| 2013 | 4 | One-step Generation Of Mice Carrying Reporter And Conditional Alleles By CRISPR/Cas-mediated Genome Engineering IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The type II bacterial CRISPR/Cas system is a novel genome-engineering technology with the ease of multiplexed gene targeting. Here, we created reporter and conditional mutant mice … |
HUI YANG et. al. |
| 2013 | 5 | Super-enhancers In The Control Of Cell Identity And Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers … |
DENES HNISZ et. al. |
| 2013 | 6 | Microbiota Modulate Behavioral And Physiological Abnormalities Associated With Neurodevelopmental Disorders IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of … |
ELAINE Y HSIAO et. al. |
| 2013 | 7 | Role Of The Microbiota In Immunity And Inflammation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The microbiota plays a fundamental role on the induction, training, and function of the host immune system. In return, the immune system has largely evolved as a means to maintain … |
Yasmine Belkaid; Timothy W Hand; |
| 2013 | 8 | Circulating Tumor Cell Clusters Are Oligoclonal Precursors Of Breast Cancer Metastasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using mouse models with … |
NICOLA ACETO et. al. |
| 2013 | 9 | What We Talk About When We Talk About Fat IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the … |
Evan D Rosen; Bruce M Spiegelman; |
| 2013 | 10 | Microglia Promote Learning-dependent Synapse Formation Through Brain-derived Neurotrophic Factor IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of microglia in brain … |
CHRISTOPHER N PARKHURST et. al. |
| 2012 | 1 | Repurposing CRISPR As An RNA-guided Platform for Sequence-specific Control of Gene Expression IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling … |
LEI S QI et. al. |
| 2012 | 2 | Cancer Epigenetics: From Mechanism To Therapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The epigenetic regulation of DNA-templated processes has been intensely studied over the last 15 years. DNA methylation, histone modification, nucleosome remodeling, and … |
Mark A Dawson; Tony Kouzarides; |
| 2012 | 3 | Selective Inhibition Of Tumor Oncogenes By Disruption Of Super-enhancers IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor … |
JAKOB LOVÉN et. al. |
| 2012 | 4 | Mapping The Hallmarks Of Lung Adenocarcinoma With Massively Parallel Sequencing IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome … |
MARCIN IMIELINSKI et. al. |
| 2012 | 5 | Posttranscriptional Control Of T Cell Effector Function By Aerobic Glycolysis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A switch from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of … |
CHIH-HAO CHANG et. al. |
| 2012 | 6 | The Hallmarks Of Aging IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk … |
Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer; |
| 2012 | 7 | Transcriptional Amplification In Tumor Cells With Elevated C-Myc IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. The effect of high … |
CHARLES Y LIN et. al. |
| 2012 | 8 | Evolution And Impact Of Subclonal Mutations In Chronic Lymphocytic Leukemia IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating … |
DAN A LANDAU et. al. |
| 2012 | 9 | Beige Adipocytes Are A Distinct Type Of Thermogenic Fat Cell In Mouse And Human IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown … |
JUN WU et. al. |
| 2012 | 10 | Master Transcription Factors And Mediator Establish Super-enhancers At Key Cell Identity Genes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells … |
WARREN A WHYTE et. al. |
| 2011 | 1 | The Impact Of The Gut Microbiota On Human Health: An Integrative View IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The human gut harbors diverse microbes that play a fundamental role in the well-being of their host. The constituents of the microbiota–bacteria, viruses, and eukaryotes–have … |
Jose C Clemente; Luke K Ursell; Laura Wegener Parfrey; Rob Knight; |
| 2011 | 2 | MTOR Signaling In Growth Control And Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway … |
Mathieu Laplante; David M Sabatini; |
| 2011 | 3 | Tumor Metastasis: Molecular Insights And Evolving Paradigms IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically … |
Scott Valastyan; Robert A Weinberg; |
| 2011 | 4 | Hydroxylation Of 5-methylcytosine By TET1 Promotes Active DNA Demethylation In The Adult Brain IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cytosine methylation is the major covalent modification of mammalian genomic DNA and plays important roles in transcriptional regulation. The molecular mechanism underlying the … |
Junjie U Guo; Yijing Su; Chun Zhong; Guo-li Ming; Hongjun Song; |
| 2011 | 5 | Basic And Therapeutic Aspects Of Angiogenesis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and … |
Michael Potente; Holger Gerhardt; Peter Carmeliet; |
| 2011 | 6 | The Origin And Evolution Of Mutations In Acute Myeloid Leukemia IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid … |
JOHN S WELCH et. al. |
| 2011 | 7 | Oncogenic Kras Maintains Pancreatic Tumors Through Regulation Of Anabolic Glucose Metabolism IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting role is highly context dependent. Oncogenic Kras mutation is the signature event … |
HAOQIANG YING et. al. |
| 2011 | 8 | Autophagy: Renovation Of Cells And Tissues IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the lysosome. However, the purpose of autophagy is not the … |
Noboru Mizushima; Masaaki Komatsu; |
| 2011 | 9 | A CeRNA Hypothesis: The Rosetta Stone Of A Hidden RNA Language? IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs talk to each other using microRNA response elements (MREs) as … |
Leonardo Salmena; Laura Poliseno; Yvonne Tay; Lev Kats; Pier Paolo Pandolfi; |
| 2011 | 10 | MYC On The Path To Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities. MYC’s activation by … |
Chi V Dang; |
| 2010 | 1 | Hallmarks Of Cancer: The Next Generation IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for … |
Douglas Hanahan; Robert A Weinberg; |
| 2010 | 2 | Cell Signaling By Receptor Tyrosine Kinases IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected diversity in the mechanisms of their activation by growth factor ligands. Strategies for … |
Mark A Lemmon; Joseph Schlessinger; |
| 2010 | 3 | Direct Reprogramming Of Fibroblasts Into Functional Cardiomyocytes By Defined Factors IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) raises the possibility that a somatic cell could be reprogrammed to an alternative differentiated fate … |
MASAKI IEDA et. al. |
| 2010 | 4 | Two To Tango: Regulation Of Mammalian Iron Metabolism IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases. Iron metabolism is balanced by two regulatory systems, … |
Matthias W Hentze; Martina U Muckenthaler; Bruno Galy; Clara Camaschella; |
| 2010 | 5 | 53BP1 Inhibits Homologous Recombination In Brca1-deficient Cells By Blocking Resection Of DNA Breaks IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that DNA breaks … |
SAMUEL F BUNTING et. al. |
| 2010 | 6 | A Tissue-specific Atlas Of Mouse Protein Phosphorylation And Expression IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although most tissues in an organism are genetically identical, the biochemistry of each is optimized to fulfill its unique physiological roles, with important consequences for … |
EDWARD L HUTTLIN et. al. |
| 2010 | 7 | A Model For Neural Development And Treatment Of Rett Syndrome Using Human Induced Pluripotent Stem Cells IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which different combinations of genetic mutations may contribute to the phenotype. Using Rett syndrome … |
MARIA C N MARCHETTO et. al. |
| 2010 | 8 | Molecular And Cellular Approaches For Diversifying And Extending Optogenetics IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Optogenetic technologies employ light to control biological processes within targeted cells in vivo with high temporal precision. Here, we show that application of molecular … |
VIVIANA GRADINARU et. al. |
| 2010 | 9 | Methods In Mammalian Autophagy Research IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autophagy has been implicated in many physiological and pathological processes. Accordingly, there is a growing scientific need to accurately identify, quantify, and manipulate … |
Noboru Mizushima; Tamotsu Yoshimori; Beth Levine; |
| 2010 | 10 | Matrix Metalloproteinases: Regulators Of The Tumor Microenvironment IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and … |
Kai Kessenbrock; Vicki Plaks; Zena Werb; |